01. Universidade Federal Rural de Pernambuco - UFRPE (Sede)
URI permanente desta comunidadehttps://arandu.ufrpe.br/handle/123456789/1
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Resultados da Pesquisa
Item Uma breve revisão dos complexos transplatínicos na terapêutica oncológica(2023-03-24) Oliveira, Barbara Daminnicy Nogueira de; Belian, Mônica Freire; Lima, Lidiane Macêdo Alves de; http://lattes.cnpq.br/9825403406472930; http://lattes.cnpq.br/2626644337183959; http://lattes.cnpq.br/4821392524886127Drugs with potential antitumor activity are of great interest to the pharmaceutical industry, since cancer is one of the diseases that affect thousands of people around the world. Cisplatin is a platinum (2+) compound widely used in cancer chemotherapy, with excellent rates of tumor regression, however, the severe side effects and cross-resistance limit its use. Thus, cisplatin analogues compounds such as carboplatin, nedaplatin, and oxaliplatin have been developed and clinically approved. Despite this, patients who use such drugs for treatment may develop cross-resistance. In this context, the need arose to search for new complexes that make it possible to minimize side effects and cross-resistance. Among the new platinum (2+) compounds of interest with antitumor activity studied, there are complexes with trans isomerism, which, due to their different mechanisms of action when binding to nDNA nucleophiles present promising strategies to overcome the mentioned difficulties encountered by current drugs with cis isomerism. Therefore, research on antitumor activity in platinum (2+) complexes with trans isomerism is relevant, to which this work is intended. This study consists of a brief review of the literature, allowing to map examples of transplatin complexes that stand out for their cytotoxic properties, configuring them as promising antineoplastic agents.Item Trabalho de Conclusão da Residência em clínica médica de pequenos animais osteossarcoma telangiectásico canino- relato de caso(2022-02-22) Santos, Isabela Gilena Lins dos; Moura, Roseana Tereza Diniz de; http://lattes.cnpq.br/6842974413081119; http://lattes.cnpq.br/4624728538887864Axial osteosarcoma is a malignant mesenchymal tumor that mainly affects middle-aged to elderly animals of medium and large breeds. This article describes the first case of telangiectatic osteosarcoma in the state of Pernambuco. The animal initially presented a tumor in the left chest wall as the only symptom. The diagnosis was confirmed after surgical excision of the tumor and sending it for histopathology. The patient was treated with a combination of surgery and chemotherapy based on carboplatin and doxorubicin. The prognosis for the telangiectatic subtype is more unfavorable when compared to other subtypes. Patient survival time was 6 months from the onset of tumor growth.Item Trabalho de conclusão da residência em clínica médica de pequenos animais relato de caso: linfoma cutâneo epiteliotrópico em cão da raça Dogo Argentino(2021-02-24) Santos, Amanda Pina dos; Santos, Edna Michelly de Sá; http://lattes.cnpq.br/5706618430575429; http://lattes.cnpq.br/1563507337861447Lymphoma is a malignant neoplasm of hematopoietic origin that affects dogs and cats. Cutaneous lymphoma is divided from its tropism to the epithelium and only 3 to 8% of animals are affected with this neoplasm. This article describes a case report of a nine-year-old Argentine Dogo affected by cutaneous epitheliotropic lymphoma in cushions. The patient had ulcerations, erythema and nodules in the limbs with rapid evolution, in addition to severe itching throughout the body, chronic otitis and excessive leg licking. After the diagnosis, she underwent chemotherapy with Lomustine 70mg / m² and Prednisone 2mg / kg, following the guidelines in the literature. Due to a neoplasm in a cushion with bone involvement, amputation of the limb was performed and it died 48 hours after the procedure due to septic shock.Item Cisplatina: uma revisão de literatura(2021-12-23) Pinto, Eddie William Andrews; Belian, Mônica Freire; http://lattes.cnpq.br/2626644337183959; http://lattes.cnpq.br/2493612296858465Cisplatin has been the subject of several studies since its discovery in the 1960s and used as a standard compound in evaluations of the effectiveness of platinum-based chemotherapy treatments. Analyzing the mechanisms of intracellular action of cisplatin, as well as the resistance mechanisms associated with it, is of fundamental importance, since many analogous com-pounds were and are elaborated until today in order to find less adverse effects and resistance to treatment, as well as greater specificity to tumor cells and more effective intracellular toxicity. For this, it is necessary to have knowledge about cisplatin, since its mechanisms of action on DNA is a pattern observed in this compound and its analogues from later generations. With these points in mind, this monograph aimed to identify some of the important productions on cisplatin in the last 5 years through a literature review. The methodology applied for the review consists of a series of steps ranging from the choice of topic to the final writing of the review, being extremely important for a good organization, selection, analysis, interpretation, writing. In all, 46 productions were chosen for a critical analysis. Topics were separated for the interpretation of the results of the analysis of the texts on cisplatin, namely: mechanism of action, adverse effects and new technologies. The 48 productions were organized and separated into topics according to the similar perspectives between the authors and a critical summary and interpretation of these works was performed. As final considerations, the review highlighted the importance of gathering such texts on cisplatin for study and instructions on the directions and trends of new technologies, such as the use of nanoemulsions and nanocarriers for cisplatin with the objective of increasing the efficiency of chemotherapy based on this compound and reduce the side effects associated with it.