01. Universidade Federal Rural de Pernambuco - UFRPE (Sede)
URI permanente desta comunidadehttps://arandu.ufrpe.br/handle/123456789/1
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Resultados da Pesquisa
Item Componentes orgânicos voláteis (COV) como biomarcadores da COVID-19(2023-04-28) Santana, Lucas Vinnicio de Araujo; Soares, Anísio Francisco; http://lattes.cnpq.br/9044747136928972; http://lattes.cnpq.br/9709966355454943In March 2020, the World Health Organization (WHO) declared the COVID-19 pandemic when the world had already reported 118,000 cases, 4.2 thousand deaths, and 114 countries with confirmed cases. With the lack of effective treatments and vaccines, scientists turned their attention to diagnosing the disease and finding ways to prevent its transmission. Although RT-PCR testing is widely used, it has some disadvantages, such as invasiveness of sample collection, cost, and time. Detection of volatile organic compounds (VOC) has emerged as a less invasive and effective alternative for COVID-19 diagnosis. Infection by a pathogenic agent can trigger a series of changes in the organism's cellular behavior. Understanding the molecules involved in this process is critical for developing diagnostic techniques that can help combat the pandemic. To investigate the relationship between COVID-19 and organic volatile biomarkers (VOC), a systematic review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.Item Trabalho de Conclusão de Residência em área profissional da saúde em medicina veterinária saúde pública(2022-02-21) Santos, Timna de Jesus; Brandespim, Daniel Friguglietti; http://lattes.cnpq.br/0279327020788151; http://lattes.cnpq.br/5228885258257357Item Vacinas contra a COVID-19: uma revisão narrativa(2022-10-03) Siqueira, Letícia Gabriela Ferreira; Cavalcanti, Yone Vila Nova; http://lattes.cnpq.br/3476206328790443; http://lattes.cnpq.br/9505103819778030The number of cases of people infected with the Sars-Cov-2 virus, in 2020, grew considerably and expanded beyond the territorial limits of Wuhan, a city located in China, where the first cases of coronavirus were reported in 2019. Knowledge about the new strain of coronavirus was scarce, on the other hand, the symptoms worsened the health status of patients and the number of deaths reached alarming rates. In this pursuit, scientists from all over the world produced knowledge about the disease, seeking treatment methods and a vaccine capable of immunizing the population against COVID-19. In this context, this study aimed to analyze studies available in the literature that deal with the characteristics of vaccines approved by National Health Surveillance Agency (ANVISA) regarding infection caused by the Sars-Cov-2 virus. To this end, the following specific objectives were considered: to understand, in the light of the literature, the effectiveness of vaccines against COVID-19 used in Brazilian territory; to identify the adverse effects caused by the immunizer against the Sars-Cov-2 virus; and, present the technological platforms of the COVID-19 vaccines that are commercialized. A literature review was carried out. A descriptive bibliographic research based on a qualitative approach was built. The search for the analyzed studies was carried out in the PubMed and Latin American and Caribbean Literature on Health Sciences (LILACS) databases, specifically, dating from the years 2021 to 2022. The results indicate that, in Brazil, four vaccines against COVID-19 can be used by the population, as regulated by ANVISA: At the end of these three stages of project development, four main COVID-19 vaccines in Brazil resulted: Astrazeneca, Coronavac, Janssen and Pfizer. In addition, it was found that Brazilians follow the recommendations indicated by the Ministry of Health and, therefore, most completed the vaccination schedule. Notably, each vaccine has side effects that can vary from individual to individual and it has been proven through studies that vaccines are efficient and, therefore, reduce the symptoms caused by the virus and, consequently, avoid serious complications of the disease that can lead people infected to death.Item Estudo in silico de derivados naftoquinônicos potenciais inibidores da principal protease do SARS-CoV-2(2020-11-05) Alencar, Natanael Ferreira de; Camara, Celso de Amorim; http://lattes.cnpq.br/4500025814149366; http://lattes.cnpq.br/7715134143959483Item Reposicionamento de fármacos como estratégia no tratamento da COVID-19: uma ênfase em antivirais análogos de nucleosídeos/nucleotídeos(2021-12-16) Silva, Cecilãne Regina Dioclecia da; Oliveira, Ronaldo Nascimento de; http://lattes.cnpq.br/9071551767043294; http://lattes.cnpq.br/1016957179784096In December 2019, a new strain of coronavirus was identified. The SARS-CoV-2 virus is the cause of severe acute respiratory syndrome, being popularly known as COVID-19. COVID-19 has spread throughout the world, being declared a pandemic on March 11, 2020, by the World Health Organization. This disease has already decimated about 5.22 million of the world's population. As it is a new virus, there is still no effective treatment. A generally faster strategy is the repositioning of drugs that have already been approved by competent agencies to treat other diseases, which may, after clinical studies, be indicated to treat the symptoms caused by SARS-CoV-2. The drugs used in these treatments, depending on the stage of the disease, whether effective or not to some degree, were galidesivir, remdesivir, favipiravir, sofosbuvir, tenofovir and ribavirin. It can highlight remdesivir, favipiravir and galidesivir because of their promising tests. This review focused on the last five drugs mentioned, which are nucle-oside/nucleotide analogues. A literature review was carried out with data collection on repo-sitioned drugs according to their effectiveness in the treatment of coronavirus. Thus, we pre-sent an overview of the existing drugs that are being or have been used to reduce the effects of COVID-19. With a view to developing a new specific drug to treat the disease caused by the SARS-CoV-2 virus.Item Relato de caso - Pesquisa de SARS-COV-2 em embalagens, master box e pescado beneficiado(2020-12-23) Nunes, Jeanne Tavares; Rolim, Maria Betânia de Queiroz; http://lattes.cnpq.br/5676854885081836; http://lattes.cnpq.br/8650187266354131The Compulsory Supervised Internship is part of curriculum of the Bachelor of Veterinary Medicine course at Federal Rural University of Pernambuco (UFRPE). This was held at Carapitanga Indústria de Pescados do Brasil LTDA., located in the municipality of Jaboatão dos Guararapes-PE during the period from August 31 to November 16, 2020. The activities of assisting employees in the fish recepcion sector and the quality control laboratory (QC); monitor the physical chemical analyzes of raw materials and water; monitor the production, packaging and shipping sector. In view of the challenges inherent to the pandemic of the new coronavírus (SARS-CoV-2) that started in Brazil in February, 2020 the present work had the general objective of describing the place ond activities developed in the internship period; and, as a specific objective, to report research on SARS-CoV-2 in the packaging, master box and procesed fish. The internship was extremely importante for professional and personal grownt. Through is execution, it was possible to acquire experience in the area of inspection of products of animal origin.