01. Universidade Federal Rural de Pernambuco - UFRPE (Sede)
URI permanente desta comunidadehttps://arandu.ufrpe.br/handle/123456789/1
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Item Avaliação da cafeína no controle da infecção experimental de macrófago por Salmonella typhimurium(2019) Almeida, Ingrydt de Alcântara; Lima Filho, José Vitor Moreira; Tavares, Lethicia Souza; http://lattes.cnpq.br/4128808335995892; http://lattes.cnpq.br/9476972124107533; http://lattes.cnpq.br/6015462685217823Salmonellosis is an infectious disease transmitted mainly by foods contaminated with bacteria of the genus Salmonella, among them Salmonella enterica serotype Typhimurium, which can cause gastroenteritis until sepsis and septic shock in groups at risk. Organic compounds for pharmacological purposes are being increasingly tested. Among these compounds, caffeine (1,3,7-trimethylxanthine), one of the most used pharmacological and psychostimulant substances in the world. Severalstudies have demonstrated its role as a therapeutic adjunct, immunomodulator and adenosine receptor antagonist (ARs). In view of this, the objective was to evaluate the immunomodulatory potential of caffeine in peritoneal macrophages infected with Salmonella enterica Sor. Typhimurium. For this, in vitro tests were performed with cultures of macrophages exposed to caffeine concentrations to determine the degree of cytotoxicity of the compound; curative and preventive tests of cell viability, in order to evaluate cellular survival and quantification of intracellular bacteria, aiming to analyze the clearance of the pathogen from the intracellular medium. A direct antibacterial activity test was also carried out to evaluate the efficacy of caffeine in preventing the development of S. typhimurium. The results demonstrated that caffeine did not produce a toxic effect on the uninfected macrophages at the concentrations used, promoted a greater viability of the infected macrophages, but was not able to act as a direct bactericide. Caffeine contributed to the survival of macrophages infected with S. Typhimurium, having potential for the control of bacterial infections.Item Relatório de Estagio Supervisionado Obrigatório (ESO): Descrição de atividades realizadas em Clínica Médica e Cirúrgica de Pequenos Animais relato de caso: linfangiectasia em cão da raça Yorkshire(2019-07-15) Santana, Edvan Cleison de; Araujo, Carolina Akiko Sato Cabral de; http://lattes.cnpq.br/5868230858347175The Mandatory Supervised Internship is a very relevant moment in the learning process for students of the veterinary medicine course, since it is possible to make a parallel between theory and practice, an approach that is fundamental to our professional training. The purpose of this report was to describe the activities carried out at the (UFRPE) campus, SEDE - Recife - PE, in the areas of Small Animal Clinical and Surgical Clinic under the supervision of the veterinary doctors, Dr. Paula Gabriela da Silva Cardoso and Dr. Robério Silveira de Siqueira Filho, as well as follow the cases attended and experienced in this place, highlighting the case report suggestive of Intestinal Lymphangiectasia in a 6 - year - old Yorkshire male. The activities were developed during the period from March 12, 2019 to June 21, 2019, making a total of 420 hours of training in which, in the morning, follow-up of clinical cases that were previously scheduled and in the afternoon , follow - up of surgical procedures that were referred by clinicians and previously scheduled by surgeons. The data covered in this report were obtained through clinical records, anamnesis, physical and clinical examination of the animals, as well as through complementary examinations performed in the consultation procedure and after it, the surgical procedures happened during the routine of the hospital operating in the sector of surgery. In this report, it was chosen to highlight the case report suggestive of intestinal lymphangiectasia, this pathology is a disorder of the lymphatic system of dogs and can rarely affect cats where the leakage of lymphatic fat into the wall of the intestine can lead to the formation of granuloma, which exacerbates lymphatic obstruction and may result in protein-losing enteropathy, where the animal may present edema, ascites or pleural effusion. Follow - up was carried out in the clinical examination of the animal and evaluation of the complementary tests with emphasis on ultrasonography, where it was observed thickening of intestinal loops, which further reinforces the suspicion of intestinal lymphangiectasia. The animal is doing the treatment recommended with corticoid, diet with low fat content and high percentage of protein and so far has responded satisfactoril, however, biopsy and histopathological examination are still necessary to reach a definitive diagnosis. Based on the above, it can be concluded that ESO activities were extremely important to understand the hospital's functioning, to know its casuistry and to put into practice the knowledge acquired during the course.