Lymphoma is a malignant neoplasm of hematopoietic origin that affects dogs and cats. Cutaneous lymphoma is divided from its tropism to the epithelium and only 3 to 8% of animals are affected with this neoplasm. This article describes a case report of a nine-year-old Argentine Dogo affected by cutaneous epitheliotropic lymphoma in cushions. The patient had ulcerations, erythema and nodules in the limbs with rapid evolution, in addition to severe itching throughout the body, chronic otitis and excessive leg licking. After the diagnosis, she underwent chemotherapy with Lomustine 70mg / m² and Prednisone 2mg / kg, following the guidelines in the literature. Due to a neoplasm in a cushion with bone involvement, amputation of the limb was performed and it died 48 hours after the procedure due to septic shock.
