01. Universidade Federal Rural de Pernambuco - UFRPE (Sede)
URI permanente desta comunidadehttps://arandu.ufrpe.br/handle/123456789/1
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Item Nusinersena (Spinraza) na intervenção da atrofia muscular espinhal tipo I versus ausência de tratamento medicamentoso sob a ótica do custo-efetividade: uma revisão sistemática(2021-06-18) Barros, Arao Vargas dos Santos; Gomes, Sónia Maria Fonseca Pereira Oliveira; http://lattes.cnpq.br/9795791528582607; http://lattes.cnpq.br/7578625933293067Spinal Muscular Atrophy (SMA) is a rare and devastating disease for which new disease-modifying drugs have recently been approved by the world's leading regulatory agencies. Given the growing importance of economic considerations in evaluating the incorporation of health technologies into Brazilian’s public health system, this review summarizes the studies that assess the cost-effectiveness of type I SMA and the economic evaluations of treatments via Nusinersen versus conventional treatment. A systematic literature review in Medline via PubMed, Lilacs via BVS and SciELO up to December 31, 2020 was conducted in accordance with PRISMA’s guidelines. The methodology allowed to clearly identify the cost-effective relationship of treatment based only on supportive therapy versus drug treatment via Nusinersen. It wa concluded that drug treatment is not cost-effective in relation to supportive therapy, but it brings favorable clinical, financial, and psychological benefits to the patient and their families. Studies focusing on health technology assessments are still quite scarce, therefore, they lack more in-depth research in this area, where resources are insufficient and, therefore, absorb a large part of the government budget.Item Estudo in vitro de avaliação da eficácia de novos compostos derivados de triazol frente a cepas sensíveis de Mycobacterium tuberculosis(2021-07-15) Rodrigues, Danielle Martiniano da Silva; Porto, Ana Lúcia Figueiredo; Pimentel, Lílian Maria Lapa Montenegro; http://lattes.cnpq.br/6066865382706623; http://lattes.cnpq.br/4989617783837981; http://lattes.cnpq.br/3260001484566380Tuberculosis is an infectious disease responsible for a high number of cases worldwide. Caused by the Mycobacterium tuberculosis species, it is transmitted from person to person through the airway, through the inhalation of bacilli from an infected individual, with positive bacilloscopy. Conventional treatment consists of the use of four first-line drugs: rifampicin, ethambutol, isoniazid and pyrazinamide. As a result of low therapeutic adherence, the world is currently facing a major problem of bacterial resistance, which makes treatment difficult, making it more toxic and longer, and may last for up to two years. For this reason, it is necessary to develop new molecules capable of eliminating the bacillus that causes tuberculosis quickly and with little or no adverse effects to be used in the treatment. Most of the drugs currently used are composed of heterocyclic structures, as well as many compounds under development that show promising results. In particular a class of compounds, the triazoles, which have wide biological application. Therefore, this study aimed to evaluate heterocyclic compounds derived from triazoles against sensitive strains of Mycobacterium tuberculosis, as candidates for new molecules for the treatment of tuberculosis, through in vitro biological activity studies. The minimum inhibitory concentration index and cytotoxicity in macrophage strain Raw 264.7 and HepG2 hepatocytes of triazole-derived compounds were evaluated, as well as the type of interaction they present with first-line drugs for the treatment of tuberculosis. All compounds showed low to relevant activity against the bacillus, with MIC ranging from 64 to 4 μg/ml for the H37Rv strain and >64 to 8 μg/ml for the H37Ra strain. The compounds with the best results were A48 and A51, selected for evaluation of the activity of the fractioned inhibitory concentration index, with the drugs rifampicin and ethambutol, in which both were indifferent. The results obtained in this study indicate the mycobacterial inhibitory action of the evaluated triazole derivatives, as possible pharmacological agents, offering parameters for the follow-up of in vitro tests.Item Uso da anfoterecina B intralesional como coadjuvante no tratamento da esporotricose resistente a itraconazol: relato de caso(2021-12-07) Moscatelli, André Luís Albuquerque Prohaska; Cavalcanti, Erika Fernanda Torres Samico Fernandes; http://lattes.cnpq.br/5256493441853885; http://lattes.cnpq.br/4720437091233362Item Monitoramento tecnológico de terapêuticas utilizadas para prevenção e tratamento da síndrome alcoólica fetal do período pré ao pós-natal(2022-05-25) Silva, Maria Letícia Santos Carnaúba da; Cadena, Pabyton Gonçalves; http://lattes.cnpq.br/0655014992762819; http://lattes.cnpq.br/8227010743353722Fetal alcohol syndrome (FAS) is the most severe form that fetal alcohol spectrum disorder (FASD) can take. Its incidence is six to nine cases per 1000 live births, and it affects as many people as other developmental disorders such as anencephaly and Down syndrome. It is a public health problem. Despite this, the main strategy to prevent it consists of alcohol abstinence during pregnancy, which is flawed when you consider the number of women who consume alcohol unaware of their pregnancy, and those who are addicted to it or abuse the substance. And the treatment strategies are still very much focused on educational resources, because the damage to the central nervous system and to the growth of other affected organs cannot yet been reversed. Therefore, the objective of this study was to perform a technological monitoring of the therapeutic measures used to mitigate, treat, and prevent fetal alcoholism syndrome from the prenatal to the postnatal period. To this end, the main national and international databases of articles and patents were used. The search was made using keywords in Portuguese and English. This was followed by an analysis to filter the documents with the inclusion and exclusion criteria adopted in this research. With the data obtained it was possible to observe that the United States was the country with the greatest presence in the publication of articles (65.3%) and in the filing of patents (41.5%). Research institutes were the main patent depositors (34.1%). Much of the research used animal models, with murine and the fish Danio rerio being the most frequent, in articles and in patent documents. Most of the treatments found were administered in the prenatal period, with growth abnormalities as the target, considering the range of systems and organs that can be affected within this group. The most commonly found therapies were those capable of blocking the development of fetal alcohol syndrome, preventing its pathology from appearing. Most of the papers found coming from the United States, can be considered a consequence of the recognition of FAS as a public health problem since the 1980s and its encouragement of research in the area. The large use of murine animals found here is due to their similarity to humans in that both are placental mammals, and the growth of zebrafish as a model FAS animal seen here is due to their transparent eggs, allowing visualization of embryonic development. Administration in the prenatal period is probably due to the greater ease of providing treatment through the mother, and there is a greater chance of blocking the teratogenicity of alcohol. Blocking the development of FAS was the most commonly found strategy probably because of the irreversibility of damage to the central nervous system once it arises. With the present research, it was possible to conclude that the production of articles in the area is still greater than that of patents, and most studies are still limited to tests in animal models, in need of further clinical testing.Item Avaliação do perfil epidemiológico das pacientes atendidas no Núcleo de Saúde da UFRPE portadoras de vulvovaginites(Universidade Federal Rural de Pernambuco (SEDE); Núcleo de Atenção e Promoção à Saúde, 2009) Dimech, Gustavo SantiagoOs corrimentos vaginais são, as principais queixas das mulheres atendidas em unidades de saúde onde é realizada a coleta do exame ginecológico. Estes sinais e sintomas geralmente responsáveis pelas vulvovaginites podem interferirem no relacionamento entre os parceiros e pertencerem ao grupo das DST´S, são considerados um grande problema de saúde pública. Diante destas considerações, podemos apontar como uma das prioridades da ginecologia na atenção à saúde da mulher a prevenção e a identificação precoce das vulvovaginites, de modo a oferecer tratamento adequado a cada especificidade de acometimento. Para isto, a equipe de médico ginecologista, deve ter à disposição materiais suficientes e adequados para identificar estas síndromes e assim, interromper a cadeia de transmissão. Diante desta situação, nos propomos a realizar a coleta de amostra de secreção vaginal para o exame de bacterioscopia (coloração de GRAM) de todas as mulheres que compuseram a amostra do estudo, assistidas pelo NAPS/UFRPE, assim como identificar no exame clínico fatores predisponentes as infecções e realizar a estratificação das pacientes quanto a idade, atividade sexual, patologias pré-existentes, queixas clínicas e vinculo (Estudantes, Funcionárias e Comunidade) para podermos identificar os principais agentes infectantes de cada grupo e adotarmos políticas de educação para a prevenção das infecções vaginais.