01. Universidade Federal Rural de Pernambuco - UFRPE (Sede)
URI permanente desta comunidadehttps://arandu.ufrpe.br/handle/123456789/1
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Resultados da Pesquisa
Item Detecção de doença cardiovascular ou diabetes utilizando machine learning(2024-03-07) Santos, Daniel Ramos Correia dos; Albuquerque Júnior, Gabriel Alves de; http://lattes.cnpq.br/1399502815770584Cardiovascular diseases and diabetes represent significant challenges for public health, requiring effective diagnostic and prevention approaches. This work proposes an approach based on machine learning models to support these processes. Using a database from the IBGE national health survey, the study investigated how different variables affect the detection of these diseases. Using algorithms such as Random Forest, XGBoost and SVM, predictive models were developed. The results demonstrated an accuracy of 71.96% for the Random Forest algorithm in classifying patients with cardiovascular diseases and 72.26% in classifying patients with diabetes. Analysis of the most influential variables was also carried out using the SHAP method, which revealed some insights into the data.Item Análise morfológica das gônadas de filhotes de ratas nascidos de matrizes induzidas ao diabetes gestacional e tratadas com melatonina(2019-11-29) Santos, Anthony Marcos Gomes dos; Teixeira, Álvaro Aguiar Coelho; Melo, Ismaela Maria Ferreira de; http://lattes.cnpq.br/3537458174521270; http://lattes.cnpq.br/1539131079574469; http://lattes.cnpq.br/4572948318160798Fetal complications of gestational diabetes may include macrosomia, hyperbilirubinemia, respiratory distress syndrome, polycythemia, cardiac overload, increased number of birth defects, spontaneous abortion, and intrauterine fetal death. The use of endogenous and exogenous antioxidants such as tocopherol and melatonin has been widely studied due to the fact that it is an effective treatment that helps in combating the various harms resulting from diabetes. Melatonin during pregnancy is known to contribute to hemodynamic regulation and aid in the development of offspring organs, such as the gonads, as well as to combat hepatic oxidative stress. Thus, the aim of this paper is to test the hypothesis that melatonin administered during pregnancy in rats may prevent the deleterious effects produced by gestational diabetes on the offspring's gonads. The gonads were analyzed histologically, morphometrically and immunohistochemically at 30 and 60 postnatal. Fifteen 90-day-old virgin albino rats (Rattus norvegicus albinus), weighing approximately close of 200g, from the Wistar strain, from the Department of Animal Morphology and Physiology at the Federal Rural University of Pernambuco, were divided into three groups: I - Puppies (n = 12) born from non-diabetic mothers, kept in a 12/12 hour light / dark cycle; II - Puppies (n = 12) born from diabetes-induced mothers during pregnancy, kept in a 12/12 hour light / dark cycle and III - Puppies (n = 12) born from diabetes-induced mothers during pregnancy and treated simultaneously with melatonin, kept in light / dark cycle of 12/12. Gestational diabetes was induced after mating confirmation with intraperitoneal injections of 60 mg / kg streptozotocin. Melatonin was administered in daily injections of 0.8 mg / kg throughout pregnancy. The results revealed that gestational diabetes can interfere in the development of offspring gonads by altering their histology and morphometry, delaying their maturation. This effect could be reversed by melatonin.Item Atualizações em diabetes canina: revisão de literatura(2023-09-22) Nogueira, Higgor Raphael de Siqueira; Moura, Roseana Tereza Diniz de; http://lattes.cnpq.br/6842974413081119Item Síntese e caracterização de novos compostos de coordenação de oxidovanádio (IV) contendo ligantes podantes(2021-07-15) Silva Neto, José Paulino da; Belian, Mônica Freire; Silva, Wagner Eduardo da; http://lattes.cnpq.br/8612340815622413; http://lattes.cnpq.br/2626644337183959; http://lattes.cnpq.br/3123733088755951Since the 70’, inorganic compounds have been studied and applied as alternatives in the treatment of several diseases such as cancers, rheumatoid arthritis, and diabetes mellitus (DM). The latter is a disease that, due to its high incidence, has worrying epidemiological numbers. DM can be caused by genetic or external factors and causes serious disturbances in the metabolism of proteins, carbohydrates, and lipids, and can be classified into two subtypes. Type 1 (DM1) is caused by the non-secretion of insulin due to the autoimmune destruction of pancreatic β-cells; type 2 (DM2) occurs when cells in peripheral tissues become resistant to the chemical stimulation of the insulin. In both cases, the patients have the general picture of high blood glucose (hyperglycemia). to improve or provide alternatives to the current treatments against diabetes, compounds based on metals such as vanadium have been studied and developed, due to their already recognized antidiabetic activity. Thus, in this work, vanadium compounds were synthesized using organic ligands to providing greater absorption and fewer side effects in future applications of the compounds obtained. Furthermore, the synthesized compounds were also characterized, as well as the ligands, which underwent chemical modifications. And based on the results of spectroscopy in the infrared region, as the displacements, the lower wavenumber of the sulfone group of taurine, or the intense peak referring to the stretching of the C=O bond (1668 cm-1) in the ligand T2DO (in addition to NMR data of 1H and 13C, for this ligand) corroborate with the proposed structures and with the operation of the methodologies used. The mass spectra show strong evidence for obtaining oxovanadium complexes (IV) with the suggested structures since besides being possible to verify the peak referring to the molecular ion it is also possible to predict fragmentations in the structures of the chemical species.Item Produto funcional a base de oleaginosas, edulcorante e biomassa de banana verde(2018) Cordeiro, Joyce Ferreira da Silva; Padilha, Maria do Rosário de Fátima; http://lattes.cnpq.br/9689966677422344; http://lattes.cnpq.br/1058101019005469