01.1 - Graduação (Sede)
URI permanente desta comunidadehttps://arandu.ufrpe.br/handle/123456789/2
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6 resultados
Resultados da Pesquisa
Item Lesão em plano nasal em um cão com leishmaniose: relato de caso(2024-07-19) Albuquerque, Juliana Maria de Oliveira; Santos, Edna Michelly de Sá; http://lattes.cnpq.br/5706618430575429; http://lattes.cnpq.br/7811017024129430This work aims to describe the activities carried out during the Mandatory Supervised Internship (ESO), in the area of Clinical Medicine with a focus on Veterinary Dermatology. Divided into two parts, the first developed at the Experimental Laboratory of Chemotherapy in Veterinary Parasitology (LEQPV), under the supervision of Prof. Dr. Júlio Israel Fernandes and the second, at the Univet Barra Veterinary Clinic, under the supervision of M. V Roberto dos Santos Teixeira, under guidance from Prof. Dr. Edna Michelly de Sá Santos. Both sites are located in the state of Rio de Janeiro and were carried out from April 8, 2024 to June 21, 2024, totaling 420 hours. The activities carried out were monitoring and assistance in consultations, carrying out low-complexity procedures, collaboration in the imaging sector and infirmary. This report describes the characteristics and case studies of the locations during the internship period. It will also report a case of lesion in the nasal plane in a dog with visceral leishmaniasis, of no defined breed, 5 years old, male, castrated, 11k, which in the nasal mirror presented an erythematous, non-pruritic, depigmented, ulcerated lesion, with loss of architecture and hyperkeratosis, caused by a probable immune-mediated action of Leishmaniasis.Item Microrganismos fotossintetizantes como potencial fonte de moléculas bioativas contra Leishmania spp.: uma revisão(2023-08-14) Silva, Sabrina Swan Souza da; Bezerra, Raquel Pedrosa; Andrade, Alexsandra Frazão de; http://lattes.cnpq.br/8560904255362766; http://lattes.cnpq.br/1466206759539320; http://lattes.cnpq.br/8504258200413633Leishmaniasis are infectious diseases caused by protozoan parasites of the genus Leishmania and represent a serious public health problem with global impact, affecting thousands of people every day. The drugs currently available for treatment are based on pentavalent antimonials that have adverse side effects with cases of resistance and ineffectiveness being frequently reported. Thus, photosynthetic microorganisms (microalgae and cyanobacteria) are a wide source of compounds that can be used in the treatment of various diseases, and due to their rapid growth combined with their minimum nutritional requirements. they have a reduced production cost, making them strong candidates as raw material for the development of new medicines. The search was conducted in databases such as Google Scholar, ScienceDirect, National Center for Biotechnology Infozmation (NCBI) and Virtual Health Library (VHL) using the terms alone and in combination to identify the articles: cyanobacteria, microalgae, photosynthetic microorganisms, bioactives, antileishmanial, antiprotozoal. The inclusion criteria for this review were original articles describing the antiparasitic activity of extracts or compounds isolated from cyanobacteria and microalgae against Leishmania infection. Bibliographical references of the included articles were checked to identify possible eligible articles. In total, eleven articles were selected and analyzed based on the species of microorganisms, bioactive compounds, and their minimum concentration to reduce 50% of the parasite population (IC5o). Cyanobacteria were the most studied group, with an emphasis on the genus Lyngbya, while there was only one study using three genera of microalgae (Nannochloris spp., Picochlorum sp. and Desmochloris sp.). The in vitro studies found reported the use of peptides as the main bioactive with anti-Leishmania activity, with the ticonamide A peptide, which presented the lowest ICso value (1.14 FM), and the almiramide B and almiramide C peptides, the most selective for the parasite, with IS values of 21.7 and 17.4, respectively. Therefore, peptides from photosynthetic microorganisms are a promising source for the development of future pharmacological products against Leishmania.Item Síntese para obtenção do 3,7-dimetóxikaempferol visando à atividade leishmanicida(2020-10-20) Oliveira, Arthur Vinicius Teixeira de; Camara, Celso de Amorim; http://lattes.cnpq.br/4500025814149366; http://lattes.cnpq.br/3130800162465676Flavonoids are a class of substance widely distributed in the plant kingdom and are found in stems, fruits, flowers etc. Numerous studies have been carried out to deepen the knowledge of the biological activity of flavonoids, some of which have been reported as antimicrobial, anti-inflammatory and antiviral activities. The present work aims to characterize methoxylated and benzylated derivatives of naringenin (9) in addition to testing protective reactions for future prototypes of leishmanicidal drugs, through changes in flavonoids. In this work, (9) was used as starting material for future reactions one of which being the methylation reaction regioselective to obtain 7-methoxy-naringenin, using dimethyl sulfate and potassium carbonate in acetone at room temperature, yielding 72%, and then the product formed is subjected to a protection reaction using benzyl bromide, however under the conditions tested the opening of ring C occurred , it was necessary to test other means of protection using silicon reagents and cyclization alternatives in an attempt to supply the desired products. The products were characterized by the usual methods in the literature and available in the research group, such as NMR, infrared and melting point.Item Análise epidemiológica das notificações das leishmanioses e leptospirose humana no estado de Alagoas, Nordeste do Brasil(2020-11-06) Bugarim Neto, Clarício Alvim; Barros, Mércia Rodrigues; http://lattes.cnpq.br/1935392548217410; http://lattes.cnpq.br/9863818675601439The Compulsory Supervised Internship (ESO) is part of the curricular matrix for completing the Bachelor's Degree in Veterinary Medicine at the “Universidade Feral Rural de Pernambuco” (UFRPE). The student completed his total workload of 420 hours, from August 17 to October 30, 2020. Veterinary physicians professionals play an important role in Public Health, which constitutes an eminent field of interdisciplinary performance, through the application of knowledge professionals, aiming at the prevention of diseases or injuries and the promotion and recovery of animal and human health. The present work of conclusion of the course contains the description of the activities developed in the “Superintendência de Vigilância em Saúde” (SUVISA), which is an organ belonging to the “Secretaria de Estado da Saúde de Alagoas” (SESAU) and to report an epidemiological analysis of the notifications of leishmaniasis and leptospirosis in the state of Alagoas that was carried out during the internship period. Surveillance aims at the continuous observation of the distribution and incidence of diseases through the systematic collection, consolidation and evaluation of reports, regulating the dissemination of this information to the entire population. In the health field, surveillance is related to the practices of care and promotion of it to citizens and to the mechanisms adopted for disease prevention. The activities developed provided constructive moments, also promoting criticality within the moral and ethical-professional precepts. ESO contributed greatly to the level of practical learning, allowing us to observe the importance of integration between the services provided by the Unified Health System and the need for attention from new veterinary medical professionals to the concept of One Health, which seeks effort collaborative work of several professionals who work locally, nationally and globally, to achieve optimal health for people, animals and our environment.Item Relatório de Estágio Supervisionado Obrigatório (ESO), realizado na Clínica Veterinária Arionaldo de Sá - Recife. Leishmaniose Canina - Relato de caso(2020-09-23) Pires, Bruna Menezes; Andrade, Lílian Sabrina Silvestre de; http://lattes.cnpq.br/0894888392191039; http://lattes.cnpq.br/2826454514949845This report is the result of the Mandatory Supervised Internship in Veterinary Medicine held at Clínica Veterinária Arionaldo de Sá, located in the city of Recife, from March 2, 2020 to June 12, 2020, as a partial requirement for completing the course. The objective was to follow the clinic routine and classes a case of interest. During the internship period, it was possible to select a case of a dog diagnosed with leishmaniasis. After clinical evaluation of the animal, hospitalization was indicated where it had intensive monitoring and evolution of the condition. It was an extremely important and indispensable moment for professional growth and training. It allow the visualization and application of the knowledge acquired at the university, now in professional life, as well as making contacts with experienced professional in the desired area.Item Detecção de Leishmania (Viannia) braziliensis através de PCR convencional e qPCR em amostras de saliva de pacientes de região endêmica do estado de Pernambuco(2019) Lima, Karina Patricia Baracho de; Brito, Maria Edileuza Felinto de; Monteiro, Juliana Figueirêdo da Costa Lima Suassuna; http://lattes.cnpq.br/6961338838328619; http://lattes.cnpq.br/4488600767130952; http://lattes.cnpq.br/9202807842046741Leishmaniasis is caused by several protozoan species of the genus Leishmania, which affect the skin and or mucous membranes and viscera. These diseases are characterized by their clinical and epidemiological manifestations. The species of L. (Viannia) braziliensis (the main one found in Pernambuco) can cause a cutaneous form - evolving to spontaneous cure; as a mucosa formed by American tegumentary leishmaniasis (ACL). The research participants were from both sexes, with varied ages, coming from several regions of the Metropolitan Region of Recife, Pernambuco, Brazil. The patients were recruited after anamnesis from the need for technical and dermatological assistance at Oswaldo Cruz Hospital and where saliva samples were collected through the noninvasive collection method. These were transported to the Immunoparasitology Laboratory of the Immunology Department of the Aggeu Magalhães Institute - FIOCRUZ-PE, where they were submitted to molecular tests (PCR and qPCR). The molecular targeting was kDNA, specific for the diagnosis of Leishmania (V.) braziliensis. In addition, experimental tests were performed to identify the disease. From the total of 41 salivary solution samples, 26 showed positivity in both molecular tests for LTA. The noninvasive collection is a sensitive therapy, practical and comfortable to the patient, allowing detection and quantification by PCR and qPCR of Leishmania spp. DNA, the saliva utilized in the diagnostic technique may help in the confirmation of LTA, aiming at a better prognosis for patients.