01. Universidade Federal Rural de Pernambuco - UFRPE (Sede)
URI permanente desta comunidadehttps://arandu.ufrpe.br/handle/123456789/1
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Item Perfil de sensibilidade e resistência em isolados de cães e gatos com cistite atendidos no Hospital Veterinário da Universidade Federal Rural de Pernambuco(2021-02-25) Silva, Samuel Souza; Cavalcanti, Erika Fernanda Torres Samico Fernandes; http://lattes.cnpq.br/5256493441853885; http://lattes.cnpq.br/6075156423779866Item Listeriose em ruminantes e sua importância como zoonose(2017-01-04) Souza, Leonardo Magno de; Souto, Rodolfo José Cavalcanti; http://lattes.cnpq.br/4263478911176230; http://lattes.cnpq.br/9374224266583090Listeriosis is an infectious disease caused by Gram-positive bacteria. This bacteria, called Listeria monocytogenes, is a facultative intracellular microorganism that has a predilection for causing infections of the central nervous system (CNS) in humans and domestic animals. In addition, it also may affect several animal species, inducing various forms of clinical manifestation, including septicemia of neonates with abscesses in viscera such as liver and spleen, abortion, neonatal death, ophthalmitis, and neurological disease as meningoencephalitis. Moreover, only one clinical form has seen in previous outbreaks. Several factors favor bacterial growth as poor quality silage (pH above 5.5) favors; other sources of infection include contaminated soil and food, and feces or milk from carried animal. In Brazil, no previous outbreaks involving L. monocytogenes have reported in humans; however some authors have conducted several researches on food and equipment involved in the manufacturing process. In a healthy population, consumption of contaminated food with L. monocytogenes usually causes a self-limiting gastroenteritis, fever, nausea, vomit, and diarrhea. Patients develop clinical signs within a few days of exposure to contaminated food. Several outbreaks involving various types of food have been described around the world. In some cases of gastroenteritis may lead to the invasive form of listeriosis in humans. Thus, it was the target of several studies as one of the major foodborne diseases for humans, causing several outbreaks around the world. This agent has a predilection for CNS tissue of humans and animals. Therefore, the purpose of this work is to clarify the interrelationship between Listeriosis as zoonosis and ruminant disease.Item Avaliação da cafeína no controle da infecção experimental de macrófago por Salmonella typhimurium(2019) Almeida, Ingrydt de Alcântara; Lima Filho, José Vitor Moreira; Tavares, Lethicia Souza; http://lattes.cnpq.br/4128808335995892; http://lattes.cnpq.br/9476972124107533; http://lattes.cnpq.br/6015462685217823Salmonellosis is an infectious disease transmitted mainly by foods contaminated with bacteria of the genus Salmonella, among them Salmonella enterica serotype Typhimurium, which can cause gastroenteritis until sepsis and septic shock in groups at risk. Organic compounds for pharmacological purposes are being increasingly tested. Among these compounds, caffeine (1,3,7-trimethylxanthine), one of the most used pharmacological and psychostimulant substances in the world. Severalstudies have demonstrated its role as a therapeutic adjunct, immunomodulator and adenosine receptor antagonist (ARs). In view of this, the objective was to evaluate the immunomodulatory potential of caffeine in peritoneal macrophages infected with Salmonella enterica Sor. Typhimurium. For this, in vitro tests were performed with cultures of macrophages exposed to caffeine concentrations to determine the degree of cytotoxicity of the compound; curative and preventive tests of cell viability, in order to evaluate cellular survival and quantification of intracellular bacteria, aiming to analyze the clearance of the pathogen from the intracellular medium. A direct antibacterial activity test was also carried out to evaluate the efficacy of caffeine in preventing the development of S. typhimurium. The results demonstrated that caffeine did not produce a toxic effect on the uninfected macrophages at the concentrations used, promoted a greater viability of the infected macrophages, but was not able to act as a direct bactericide. Caffeine contributed to the survival of macrophages infected with S. Typhimurium, having potential for the control of bacterial infections.