01. Universidade Federal Rural de Pernambuco - UFRPE (Sede)
URI permanente desta comunidadehttps://arandu.ufrpe.br/handle/123456789/1
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Resultados da Pesquisa
Item Uma breve revisão dos complexos transplatínicos na terapêutica oncológica(2023-03-24) Oliveira, Barbara Daminnicy Nogueira de; Belian, Mônica Freire; Lima, Lidiane Macêdo Alves de; http://lattes.cnpq.br/9825403406472930; http://lattes.cnpq.br/2626644337183959; http://lattes.cnpq.br/4821392524886127Drugs with potential antitumor activity are of great interest to the pharmaceutical industry, since cancer is one of the diseases that affect thousands of people around the world. Cisplatin is a platinum (2+) compound widely used in cancer chemotherapy, with excellent rates of tumor regression, however, the severe side effects and cross-resistance limit its use. Thus, cisplatin analogues compounds such as carboplatin, nedaplatin, and oxaliplatin have been developed and clinically approved. Despite this, patients who use such drugs for treatment may develop cross-resistance. In this context, the need arose to search for new complexes that make it possible to minimize side effects and cross-resistance. Among the new platinum (2+) compounds of interest with antitumor activity studied, there are complexes with trans isomerism, which, due to their different mechanisms of action when binding to nDNA nucleophiles present promising strategies to overcome the mentioned difficulties encountered by current drugs with cis isomerism. Therefore, research on antitumor activity in platinum (2+) complexes with trans isomerism is relevant, to which this work is intended. This study consists of a brief review of the literature, allowing to map examples of transplatin complexes that stand out for their cytotoxic properties, configuring them as promising antineoplastic agents.Item Cisplatina: uma revisão de literatura(2021-12-23) Pinto, Eddie William Andrews; Belian, Mônica Freire; http://lattes.cnpq.br/2626644337183959; http://lattes.cnpq.br/2493612296858465Cisplatin has been the subject of several studies since its discovery in the 1960s and used as a standard compound in evaluations of the effectiveness of platinum-based chemotherapy treatments. Analyzing the mechanisms of intracellular action of cisplatin, as well as the resistance mechanisms associated with it, is of fundamental importance, since many analogous com-pounds were and are elaborated until today in order to find less adverse effects and resistance to treatment, as well as greater specificity to tumor cells and more effective intracellular toxicity. For this, it is necessary to have knowledge about cisplatin, since its mechanisms of action on DNA is a pattern observed in this compound and its analogues from later generations. With these points in mind, this monograph aimed to identify some of the important productions on cisplatin in the last 5 years through a literature review. The methodology applied for the review consists of a series of steps ranging from the choice of topic to the final writing of the review, being extremely important for a good organization, selection, analysis, interpretation, writing. In all, 46 productions were chosen for a critical analysis. Topics were separated for the interpretation of the results of the analysis of the texts on cisplatin, namely: mechanism of action, adverse effects and new technologies. The 48 productions were organized and separated into topics according to the similar perspectives between the authors and a critical summary and interpretation of these works was performed. As final considerations, the review highlighted the importance of gathering such texts on cisplatin for study and instructions on the directions and trends of new technologies, such as the use of nanoemulsions and nanocarriers for cisplatin with the objective of increasing the efficiency of chemotherapy based on this compound and reduce the side effects associated with it.Item Avaliação do potencial antitumoral in vitro e da atividade imunomoduladora do composto mesoiônico 5-(4-clorofenil)-3-metil-4-fenil-1,3-tiazólio-2-tiolato (MI-2)(2020-11-04) Andrade, Bárbara Fernanda Pessoa de; Silva, Elayne Cristine Soares da; Andrade, Jeyce Kelle Ferreira de; http://lattes.cnpq.br/8970644656035762; http://lattes.cnpq.br/2064359935012193; http://lattes.cnpq.br/8580695386267290Cancer is classified by the World Health Organization (WHO) as a group of diseases, wich can develop anywhere in the body, from the uncontrolled grownth of genetically altered cells and wich have the ability to invade adjacent tissues and can therefore, if install simultaneously in more than one organ. It is considered by WHO as the second leading cause of death in the world, killing about 9.6 million people. In Brazil, according to the National Cancer Institute (INCA), it is estimated that in 2020 309,750 new cases of cancer will be registered for men and about 316,280 new cases for women. Cancer patients are usually treated with chemotherapy, radiation therapy, surgical intervention and in some cases, immunotherapy. In view of the high cost and the remarkable toxicity presented by the vast majority of treatments currently available, such as weight loss and hair, in addition to anemia, leukopenia, thrombocytopenia and immunosuppression that make them extremely vulnerable; the search for new therapeutic possibilities is necessary to increase the chances of cure and quality of life. Mesoionic compounds are a group of substances defined as heterocyclic betaines, mostly of synthetic origin, biologically active and wich have been widely studied for their chemical characteristics and diverse functions, among which the antitumor potential, which has been the object of prominence, stands out of numerous surveys. The compound used in the present work (MI-2) is one of the derivatives of the thiadiazole class mesoionics called 5-(4-chlorophenyl)-3-methyl-4-phenyl-1,3-thiazolium-2-thiolate. The objective of this work was to analyze the antitumor potential of this compound, evaluating the cytotoxicity in tumor cell lines, morphological characteristics of these cells, DNA fragmentation; in addition to the analysis of cytotoxicity in cells of the imune system of rats (Rattus novergicus). The results presented so far, demonstrate satisfactory responses in antitumor evaluation tests, especially for leukemias; and a probable low toxicity in isolated rat lymphocytes. This compound is part of an ongoing research project.