01. Universidade Federal Rural de Pernambuco - UFRPE (Sede)
URI permanente desta comunidadehttps://arandu.ufrpe.br/handle/123456789/1
Navegar
3 resultados
Resultados da Pesquisa
Item Diatomáceas do estuário do rio Sirinhaém, PE, Brasil(2021-12-09) Aguiar, Lucas Pereira de; Gama Júnior, Watson Arantes; http://lattes.cnpq.br/8692563615933473; http://lattes.cnpq.br/2086753590165553Item Atividade tripanocida de compostos bioativos oriundos de algas e cianobactérias: uma revisão(2021-12-07) Moura, Yanara Alessandra Santana; Marques, Daniela de Araújo Viana; http://lattes.cnpq.br/0788548123321981; http://lattes.cnpq.br/1018762976201930Chagas disease (CD), classified as a neglected tropical disease second to World Health Organization, is caused by the parasite Trypanosoma cruzi, which can assume two evolutive forms in the human host: trypomastigote and amastigote. DC possesses two clinical phases, the acute phase (generally asymptomatic) and the chronic phase (which can affect the cardiovascular, digestive and/or nervous systems). The currently available drugs to treat CD, benznidazole (BZN) and nifurtimox (NFX), are known for their high toxic profile, especially NFX. BZN, the first-line treatment, possesses limited efficacy in the chronic phase of CD and mechanisms of resistance had been associated to it. Thus, new compounds with trypanocidal activity are necessary to act as an alternative treatment against CD. Natural compounds are described as promising alternative for antiparasitic treatment. Algae and cyanobacteria are promising sources of bioactive compounds since they perform various biological activities reported in the literature, including antiparasitic activity. Therefore, this work aimed to make a review exploiting the antiparasitic activity of the biocompounds from algae and cyanobacteria against both trypomastigote and amastigote forms of T. cruzi. For this, it was conducted a search in Science Direct, Medline (PubMed), Web of Science (WoS), Springer Link, Wiley Online Library, Scielo, and MDPI. In total, 15 studies were included and the Rhodophyta and Ochrophyta phyla are the more studied and more promising for anti-T cruzi activity. The macroalgae Dictyota dichotoma and Ulva lactuca were the most studied. However, the highest antiparasitic activity was presented by the extract from macroalgae Stypopodium zonale, based on the extract concentration that can inhibit the parasites by 50% (IC50), while the species Tetraselmis suecica and Nostoc commune exhibited the best IC50 values among microalgae and cyanobacteria, respectively. Among all studies, only four active principles were identified, being elatol compound from Laurencia dendroidea the most promising based on its SI values for trypomastigotes (SI = 19.56) and amastigotes (SI = 26.73). The only in vivo study showed that microalgae Arthrospira maxima can be effective in T. cruzi-infected mice as treatment or prophylaxis. Although anti-T. cruzi activity of algal and cyanobacterial biocompounds is promising, further studies should exploit the mechanisms of action of the compounds, as well as new in vivo studies are required to make feasible future applications of these compounds for clinical trials in the treatment of CD.Item Controle Top-Down da comunidade fitoplanctônica em reservatórios eutróficos tropicais: um cenário de biomanipulação com a adição de cladóceros planctônicos(2019-10-18) Carneiro, Celina Rebeca Valença; Moura, Ariadne do Nascimento; http://lattes.cnpq.br/5127314582444598; http://lattes.cnpq.br/2992963543722654The growing levels of eutrophization in the aquatic ecosystems have brought attention to studies that research the control of microalgae bloom, since some of these organisms can produce toxins capable of causing damage to a large variety of living beigns. Looking for possible solutions to this ecological imbalance, there is a growth in the levels of preoccupation concerning the particularities of the phytoplankton-zooplankton relation, especially due to the direct role of the zooplankton in the dynamic of aquatic ecosystems. Therefore, this study aims to analyze the potential of cladocerans in acting on the top-down control of the phytoplanktonic biomass of the eutrophic reservoirs. The study consists of two experiments: the first was realized under controlled laboratory conditions with the phytoplanktonic community of the Apipuco's weir, in Pernambuco, and the second was realized in situ with the phytoplankton from the Tapacurá's reservoir, also in Pernambuco. Through the laboratory experiment, a significant decrease of 67.39% and 40.17% from the total biomass in the dry and wet weather periods, respectively, was observed after eight hours in the higher zooplanktonic density. On the other hand, the cladocerans were not successful with the control of the phytoplanktonic biomass through the experiment. However, the treatment with the duplicated zooplanktonic biomass from the Tapacura's reservoir was capable of significantly reducing the biomass of almost every morphofunctional groups. Besides that, in both experiments the species that presented the most linear dimension, with values between 0 and 100 μm, did not present reductions in the size in both the seasonal periods, suggesting that the cladoceran consumed them whole, while only in the experiment I species larger than 100 μm were reduced, mainly through treatments with addition of 200 and 300 ind L-1. Thus, the natural zooplanktonic community from the Tapacura's reservoir and Macrothrix spinosa demonstrate to be potential controllers of the phytoplanktonic growth in aquatic eutrophic tropical ecosystems.