01.1 - Graduação (Sede)
URI permanente desta comunidadehttps://arandu.ufrpe.br/handle/123456789/2
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Resultados da Pesquisa
Item O perfil dos cuidadores de crianças com a síndrome congênita do zika vírus no estado de Pernambuco: um estudo de caso no CERVAC(2019-12-18) Lemos, Karla da Silva Ferreira de Sousa; Xavier, Maria Gilca Pinto; http://lattes.cnpq.br/6470044940848558The Congenital Zika Virus Syndrome is a disease that has no cure, characterized by inducing a neurological malformation that causes the head circumference of the newborn measurements ≤ 32 cm. Its main form of transmission is by the Aedes Aegypti mosquito, whose reproduction depends on the poor housing conditions and sanitation. With these means, this study points out which part of society is more affected than others. That's why this research aims to trace the socioeconomic profile of caregivers of children with microcephaly by Zika virus in Pernambuco, represented by a sample taken from CERVAC. The data was collected from 11 users of the institution of a total of 13. The research was done at this center because of the ease of access to information due to resistance from the government and mothers. Because there are other centers of greater breadth and larger numbers of users. Even so, this study has its value due to the participation of the researcher together with the users throughout the treatment offered by the center.Item Frequência do polimorfismo de nucleotídeo único (SNP) rs12979860 no gene IFN-λ3 entre gestantes com complicações obstétricas infectadas pelos vírus Zika e chikungunya e repercussões neonatais(2021-12-09) Silva, Raldney Ricardo Costa da; Silva, Maria Almerice Lopes da; Braga, Maria Cynthia; http://lattes.cnpq.br/4359793845820339; http://lattes.cnpq.br/2673967607603352; http://lattes.cnpq.br/2342253724047012Zika (ZIKV) and chikungunya virus (CHIKV) infections during pregnancy have been related to adverse clinical outcomes in the mother or her fetus. Single Nucleotide Polymorphisms (SNPs), with locus in immune response genes, may be involved in the occurrence of these complications. Thus, this study aimed to describe the frequency of SNP rs12979860 (C/T) in IFN-λ3 gene among pregnant/parturient women with obstetric complications attributed or not to Zika and chikungunya fever and to evaluate neonatal repercussions. For this purpose, we compared the genotypic and allelic frequencies of rs12979860 between two women groups with obstetric complications: infected with ZIKV or CHIKV (n=122) and non-infected (n=212). Then, we related the presence of neonatal complication (n=167) and absence of neonatal complication (n=166) with the presence of maternal infection and the SNP. To identify the SNP, we performed genotyping analysis using DNA extracted from blood samples with Wizard Genomic DNA Purification kit (PROMEGA, USA). Assays were accomplished by qPCR using a TaqMan fluorescent probe system. Differences between groups were analyzed using Pearson's chi-square test (X2) at a significance level p<0.05. We employed genotypic, recessive and dominant models to test associations of genotypes. All SNPs were in Hardy-Weinberg equilibrium. In the infected pregnant women/parturients group, the frequencies of TT, CT, and CC genotypes were 18.9%, 40.1%, 41.0%, respectively. In the non-infected group, these values were 19.8%, 47.6%, 32.5%, respectively. No significant difference was observed for the association between genotypic and allelic frequencies and the acquisition of infection by ZIKV and CHIKV in pregnant women with obstetric complications. Our results point to an association between maternal CT/TT genotypes and the risk of neonatal complications (p= 0.010), although the presence of maternal arboviral infection was not associated with this outcome (p= 0.076). It is concluded, although the presence of SNP rs12979860 in pregnant women with obstetric complications was not related to the acquisition of infections by ZIKV and CHIKV and presence of infection in the mother was not related to the development of neonatal complications, the CT/TT profile maternal is a risk predictor for complications in neonates.