01.1 - Graduação (Sede)
URI permanente desta comunidadehttps://arandu.ufrpe.br/handle/123456789/2
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Resultados da Pesquisa
Item Síndrome uveodermatológica em Spitz alemão: relato de caso(2024) Garcia, Thayná Isabella Silva; Bartolomeu, Cláudio Coutinho; http://lattes.cnpq.br/7619056086707716; http://lattes.cnpq.br/0330779386400022The aim of this work is to describe the activities carried out during the Mandatory Supervised Internship (ESO), the final part of the curriculum of the Bachelor's degree in Veterinary Medicine at the Federal Rural University of Pernambuco - UFRPE. The ESO was coordinated by Professor Dr. Cláudio Coutinho Bartolomeu and carried out in two different locations in the area of small animal medical and surgical clinics. Initially, it was conducted at the mobile castramobile unit of the municipality of Olinda, on Tuesdays and Thursdays, between October 3, 2023, and February 8, 2024, under the supervision of Dr. Alecsandra de Abreu França, totaling 220 hours. Subsequently, the internship was carried out at the private veterinary clinic Day Clinic Pet, with Dr. Karina Melo, located in the Casa Forte neighborhood, in Recife, between December 11, 2023, and February 16, 2024, on Mondays, Wednesdays, and Fridays, totaling 200 hours. Together, they amounted to the 420 hours required by the discipline. During the internship, activities such as accompanying medical and dermatological consultations, collecting biological samples, medical history, physical examination, rapid testing, requesting exams, prescribing and administering medications, monitoring the evolution of clinical cases, administering vaccines and immunobiologicals, as well as performing surgical procedures of orchiectomy and hysterectomy in small animals, and making diagnoses and prognoses were carried out. Also presented in this work is the report of a clinical case followed in the private clinic of a male German Spitz, weighing 3.1 kg, 3 years and 8 months old, presenting uveitis and microphthalmia in the left eye, depigmentation in the muzzle (nose and mouth) and eyelids, and photophobia. Based on clinical findings and pre-performed exams indicating the beginning of cataract, vitreous degeneration, and vitritis, the uveodermatologic syndrome, not yet reported in German Spitz dogs, was diagnosed.Item Relatório do Estágio Supervisionado Obrigatório realizado no Hospital Veterinário da Universidade Federal Rural de Pernambuco e na Clínica Veterinarii, município de Recife - PE. Dermatomiosite em cães - Revisão de literatura(2023-09-12) Silva, Larissa Rayane Hora da; Santos, Edna Michelly de Sá; http://lattes.cnpq.br/5706618430575429; http://lattes.cnpq.br/0006466440314642The Mandatory Supervised Internship is a mandatory subject of the eleventh period of the Bachelor's degree in Veterinary Medicine at the Federal Rural University of Pernambuco, which is based on practical experience in a certain sub-area of Veterinary Medicine, for which the chosen one was the Medical Clinic of Little animals. In this sense, this report is divided into two chapters, with the first chapter aiming to describe the Mandatory Supervised Internship, its experience, and case series in the small animal clinic, being divided between the Veterinary Hospital of the Federal University of Pernambuco and the Veterinarii Clinic, from 05/29/2023 to 08/11/2023, totaling 424 hours. The second chapter aims to carry out a literature review on canine Dermatomyositis.Item Pênfigo foliáceo em um canino da raça Pit bull: relato de caso(2020-09-22) Cavalcanti, André Luiz de Aguiar; Mota, Rinaldo Aparecido; http://lattes.cnpq.br/8378380401850485The Pemphigus complex in animals is considered rare, but not so much when compared to the occurrence of other autoimmune diseases. Pemphigus Foliáceo in dogs is the most common form of pemphigus disease and is clinically characterized by intraepidermal pustules, starting on the face and ears, cushions, groin and can become multifocal or generalized in six months. As the pustules are very fragile, the lesions usually found are secondary, which can vary from dry crusts to epidermal collars, in addition to nasal depigmentation. The diagnosis is difficult because it presents similar symptoms with other diseases and because its laboratory diagnosis is more accurate with the histopathological examination of intact pustules (biopsy), which are rarely found. The treatment, despite having an individual therapeutic scheme, is based on immunosuppressing the animal in order to decrease the production of antibodies and treat opportunistic diseases. The drugs of choice depend on the clinical presentation, but it is usually prednisoline together with azathioprine as a combined immunosuppressive therapy. Use should be made daily until the disease is inactive and gradually reduce the dose until the effective minimum is reached, preferably on alternate days for remission of signs of the disease. The prognosis of pemphigus varies according to its stage and the treatment established. Pemphigus foliaceus is less severe, but without treatment it can be fatal.Item Análise do Polimorfismo -607 C/A (RS1946518) do gene IL-18 em pacientes com artrite reumatóide do estado de Pernambuco(2019-12-13) Moraes, Maísa Maria de; Maia, Maria de Mascena Diniz; Silva, Isaura Isabelle Fonseca Gomes da; http://lattes.cnpq.br/9915138553762710; http://lattes.cnpq.br/7051998554981575; http://lattes.cnpq.br/0862994383816032Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects about 1% of the world's population, affecting both sexes. However, there is a higher incidence of cases for women than men. There is still no clarity regarding the etiology of the disease, but it knows whether it includes genetic and environmental factors. An IL-18 is a proinflammatory cytokine and its high level is qualified with a severity of inflammatory, chronic and destructive diseases. Thus, this study aimed to analyze the -607 C / A polymorphism of the IL-18 gene in patients diagnosed with RA and its relationship with disease severity. A survey was conducted with 114 patients, 111 women and 3 men resident in the city of Recife-PE. Blood collection was performed and then DNA extraction was performed, followed by amplification by conventional polymerase chain reaction (PCRc). After PCR, the samples were run on blue Green loading dye (LGC) stained 2% (w / v) agarose gel and the result visualized in UV light. Statistical analyzes were performed using univariate analysis, with significance level p <0.05, applying the one-way ANOVA test. For genotypic frequency, samples were submitted to Chi-square test, considering significant p <0.05. Patients with AA genotype show a significantly higher mean for Clinical Disease Activity Index (CDAI) (25.15 ± 11.06) when compared to the other CC and CA genotypes (16.32 ± 9.26 and 20, 49 ± 9.76) respectively. These results suggest that IL-18 may be related to increased CDAI when the patient has the AA genotype. Disease Activity Score 28 (DAS 28) (p = 0.096) and Health Assessment Questionnaire (HAQ) values (p = 0.823) were not significant in relation to AA, CC and CA genotypes, showing no association of polymorphism with these activity indices, suggesting that this polymorphism is not associated with the patient's disability. The rheumatoid factor (RF) analysis showed no statistically significant results (p = 0.879) and also the erosion analysis results showed no statistical significance (p = 0.529), suggesting that IL-18 polymorphism (-607 C / A (RS1946518)) is not associated with erosion and rheumatoid factor. Thus, we can say that IL-18 (-607 C / A (RS1946518)) may be associated with disease activity when related to increased CDAI in patients with AA genotype. However, further studies are needed to better understand the association of polymorphism of other IL-18 gene regions in the development of RA.Item Estudo do polimorfismo +874 T/A do gene interferon gamma em pacientes com artrite reumatoide do estado de Pernambuco(2018) Barboza, Daniella Alves Silva Pimentel; Maia, Maria de Mascena Diniz; Silva, Isaura Isabelle Fonseca Gomes da; http://lattes.cnpq.br/9915138553762710; http://lattes.cnpq.br/7051998554981575Rheumatoid arthritis (RA) is an autoimmune disease with prevalence between 0.5% and 1% of the adult population worldwide. The etiology is still not fully understood, but it is known that hormonal, environmental and immunological factors act together in individuals with genetic predisposition. Among the genetic factors, Interferon Gamma (IFNG) +874 T/A gene polymorphism is cited as acting in several autoimmune diseases. In this sense, the objective of this work is to analyze the relation of the +874 T / A polymorphism of the IFNG gene in RA, in a population of the State of Pernambuco. The present study was composed of 127 patients and 127 healthy controls, from which the blood samples collected were used for DNA extraction. Subsequently, amplification of the extracted DNA was performed, using the allelespecific polymerase chain reaction (AS-PCR). The amplified material was subjected to 2% agarose gel electrophoresis. Statistical calculations were applied using Chi-square and Analysis of Variance. The results indicated that the + 874 T / A polymorphism of the IFNG gene is not associated to the development of RA, with genotypic distribution (TA x AA: p = 0.530 and TT x AA: p = 0.416) and allelic frequency (p = 0.851). However, individuals with TT and TA genotypes had significantly higher rates of disease activity compared to the AA genotype (DAS28: p = 0.017; CDAI: p = 0.021). Suggesting that the +874 T/A polymorphism of the IFNG gene can be considered as a marker for RA disease activity.