01. Universidade Federal Rural de Pernambuco - UFRPE (Sede)
URI permanente desta comunidadehttps://arandu.ufrpe.br/handle/123456789/1
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Item Estudo de polimorfismos no gene receptor da vitamina D em pacientes com a doença de Alzheimer(2021-12-09) Nascimento, Higor Vinicius Alves do; Souza, Paulo Roberto Eleutério de; http://lattes.cnpq.br/1971832245117283; http://lattes.cnpq.br/2776608155510414Vitamin D (VD) is a neurosteroid whose function is related to cell regulation, ion homeostasis, growth regulation and protective effect against injuries. Its deficiency may be associated with neurological disorders such as Alzheimer's disease. The effect of VD is exercised by the interaction with VD receptor, the VDR. The presence of the VDR gene is considered highly expressive, especially in the encephalon, hypothalamus and nigra substance, indicating a significant participation in the functioning of the nervous system. The VDR gene is located on the chromosome 12q13.11 and presents 14 exons. Polymorphisms in this gene have been associated with changes in its function and may influence its effects. The polymorphisms FokI (rs2228570) and TaqI (rs731236) are located in exotic regions and the BsmI (rs1544410) is located in the intronic region. Thus, this study aimed to verify the prevalence of BsmI, TaqI and FokI polymorphisms in the VDR gene in individuals with Alzheimer's disease (AD) and healthy control individuals (CS), in a population of the state of Pernambuco. A total of 78 individuals were evaluated, 39 with Alzheimer’s disease and 39 healthy controls treated in the outpatient clinic of the Hospital das Clínicas of UFPE and the characterization of genotypes was performed using the PCR-RFLP technique. The frequencies of FokI genotypes were 48.9% CC, 46.1% CT, 5% TT for the AD group and 43.6% CC, 53.9% CT and 2.5% TT for the CS group. Regarding genotypes BsmI, 15.4% AA, 53.9 AG and 30.8% GG were observed for the group with AD and 10.3% GG, 56.4% AG and 33.3% AA for the CS group. In turn, the frequencies of the TaqI genotypes for the AD group were 51.3% CT and 48.7% CC while for the CS group they were 61.5% CT and 38.5% CC. No significant difference was found when statistical analyses were performed between the groups (AD x CS) [p >0.05 for each analysis performed]. Thus, we can conclude that none of these three polymorphisms in the VDR gene seems to be involved with the susceptibility to AD in the studied population. However, new studies, including a larger number of patients, may elucidate our observed results.Item Uso da vitamina D em cães: revisão de literatura(2021-12-03) Santos, Bruna Giovanna Bezerra dos; Lima, Tayara Soares de; http://lattes.cnpq.br/3100045021780173; http://lattes.cnpq.br/4258585528881155Due to the high degree of domestication and the changes in lifestyle, breeding and consequently feeding of dogs, it is necessary to provide diets with adequate levels that meet their nutritional requirements. The deficiency of some nutrients can cause diseases, as well as the presence of some can prevent and treat disorders, as is the case of vitamin D. Vitamin D is an essential fat-soluble steroid hormone for dogs, which regulates phosphorus and calcium metabolism, and is found in compounds of animal (cholecalciferol) and plant (ergocalciferol) origin with vitamin D metabolic activity. Most animals are able to synthesize cholecalciferol by activation of 7-dehydrocholesterol by the action of ultraviolet-B light (UVB) on the skin. However, this synthesis is inefficient in dogs, requiring adequate dietary supplementation of vitamin D. In recent years, vitamin D has received more attention due to the discovery that it is not only limited to calcium homeostasis but also in the prevention and treatment of diseases such as rickets, kidney disease, heart disease, mastocytoma, lymphoma, hemangiosarcoma, and benign neoplasms, in addition to improved joint and bone health. Thus, it was aimed to conduct a literature survey that describes the actions of vitamin D and its benefits in various aspects of dog health.