Bacharelado em Ciências Biológicas (Sede)
URI permanente desta comunidadehttps://arandu.ufrpe.br/handle/123456789/5
Siglas das Coleções:
APP - Artigo Publicado em Periódico
TAE - Trabalho Apresentado em Evento
TCC - Trabalho de Conclusão de Curso
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4 resultados
Resultados da Pesquisa
Item Epidemiologia da tuberculose em Pernambuco no período de 2008 a 2018(2019-12-10) Lima, Larycia Ramos de; Cavalcanti, Yone Vila Nova; http://lattes.cnpq.br/3476206328790443Tuberculosis is one of the oldest diseases in the world. Evidence of the disease has already been found in prehistoric human bones in Germany and there are records dating back 8,000 bc. In Pernambuco, in 2018, 5,026 cases of the disease were confirmed, an increase of 9% when compared to the 2015 data (4,599). According to the State Tuberculosis Control Program of the State Department of Health (SES), the State has been reinforcing the importance of prevention and detection of the disease with municipalities, in addition to periodically conducting clinical management courses of patients for health professionals. The objective of this work was to understand what tuberculosis is, to raise information about the causes of evolution in the last 10 years, transmission, clinical manifestations and control campaigns in the State of Pernambuco. The methodology used was based on an exploratory and descriptive bibliographic review.Item Estudo in vitro de avaliação da eficácia de novos compostos derivados de triazol frente a cepas sensíveis de Mycobacterium tuberculosis(2021-07-15) Rodrigues, Danielle Martiniano da Silva; Porto, Ana Lúcia Figueiredo; Pimentel, Lílian Maria Lapa Montenegro; http://lattes.cnpq.br/6066865382706623; http://lattes.cnpq.br/4989617783837981; http://lattes.cnpq.br/3260001484566380Tuberculosis is an infectious disease responsible for a high number of cases worldwide. Caused by the Mycobacterium tuberculosis species, it is transmitted from person to person through the airway, through the inhalation of bacilli from an infected individual, with positive bacilloscopy. Conventional treatment consists of the use of four first-line drugs: rifampicin, ethambutol, isoniazid and pyrazinamide. As a result of low therapeutic adherence, the world is currently facing a major problem of bacterial resistance, which makes treatment difficult, making it more toxic and longer, and may last for up to two years. For this reason, it is necessary to develop new molecules capable of eliminating the bacillus that causes tuberculosis quickly and with little or no adverse effects to be used in the treatment. Most of the drugs currently used are composed of heterocyclic structures, as well as many compounds under development that show promising results. In particular a class of compounds, the triazoles, which have wide biological application. Therefore, this study aimed to evaluate heterocyclic compounds derived from triazoles against sensitive strains of Mycobacterium tuberculosis, as candidates for new molecules for the treatment of tuberculosis, through in vitro biological activity studies. The minimum inhibitory concentration index and cytotoxicity in macrophage strain Raw 264.7 and HepG2 hepatocytes of triazole-derived compounds were evaluated, as well as the type of interaction they present with first-line drugs for the treatment of tuberculosis. All compounds showed low to relevant activity against the bacillus, with MIC ranging from 64 to 4 μg/ml for the H37Rv strain and >64 to 8 μg/ml for the H37Ra strain. The compounds with the best results were A48 and A51, selected for evaluation of the activity of the fractioned inhibitory concentration index, with the drugs rifampicin and ethambutol, in which both were indifferent. The results obtained in this study indicate the mycobacterial inhibitory action of the evaluated triazole derivatives, as possible pharmacological agents, offering parameters for the follow-up of in vitro tests.Item Estratégias de controle da tuberculose no Brasil nos últimos 10 anos(2019) Barbosa, Gleice Kelly Torres Falcão; Cavalcanti, Yone Vila Nova; http://lattes.cnpq.br/3476206328790443; http://lattes.cnpq.br/3404618126876077Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis with great epidemiological importance due to its social complications. Even curable, it has difficulty to reduce its incidence, prevention and control. Brazil has as a challenge the fight against tuberculosis to get off the list of diseases of epidemiological importance. Sick individuals without treatment or even without proper guidance and monitoring is a challenge. This exploratory and descriptive review aimed to gather updated data on the strategies proposed and implemented by the country to fight the disease in the last 10 years. The results found show that TB cases are slowly decreasing but that in order to reach the 2035 WHO target we have a long way to go.Item Revisão bibliográfica sobre a tuberculose no município de Paulista/PE (2011-2018)(2019) Oliveira, Sheyla Soares de; Cavalcanti, Yone Vila Nova; http://lattes.cnpq.br/3476206328790443; http://lattes.cnpq.br/7185363238133469Tuberculosis (TB) is an infectious disease caused by the etiologic agent Mycobacterium tuberculosis.TB has social and epidemiological complications, important for its prevention and control. The decrease in its incidence is due to two factors, early diagnosis and prompt and successful treatment, since the major source of infection is untreated sick individuals or those with ineffective treatment that remain bacilliferous, maintaining the chain of infection. streaming. This study aimed to review from a bibliographic survey, from 2011 to 2018, about Tuberculosis in the city of Paulista/PE. The methodology used is characterized as a literature review of exploratory and descriptive character, in order to accurately search relevant data on TB and its epidemiological aspects in the city of Paulista/PE, bringing up-to-date and insightful information. In this research, it was observed that even with the control measures imposed by WHO and implemented by the Secretariat of Health the results are not very satisfactory, it is understood that a greater participation in primary care in the control of the disease and a supervision under supervision is necessary. the programs to better meet the established goals.