01.1 - Graduação (Sede)
URI permanente desta comunidadehttps://arandu.ufrpe.br/handle/123456789/2
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Resultados da Pesquisa
Item Síntese e caracterização de 2-(3-aril-1,2,4-oxadiazol-5-il)-(1E,3E)-penta-1,3-dien-1-ila(2024-03-07) Silva, Juliana Carolina do Nascimento; Freitas Filho, João Rufino de; http://lattes.cnpq.br/9252404584350850; http://lattes.cnpq.br/62314822898372301,2,4-oxadiazoles are heterocyclic compounds containing two nitrogen atoms, one oxygen atom and two double bonds in their structure and due to their low aromaticity they are called a conjugated system. Due to its notable importance of its biological properties such as: anti-inflammatory, anti-asthmatic, anti-cancer, anti-tumor, among others. In this work, the synthesis and characterization of 1,2,4-oxadiazoles from amidoximes and ethyl sorbate are described. The approach adopted was qualitative and experimental. Characterization was carried out by infrared spectroscopy and ¹H and ¹³C nuclear magnetic resonance. The results revealed that the arylamidoximes obtained by the stirring method for 24 hours showed good yields, ranging from 75% to 90%. Ethyl sorbate prepared by Fischer esterification showed a yield of 82%. However, the 1,2,4-oxadiazoles obtained by the superbase method showed yields between 45% and 50%, due to the formation of byproducts with similar polarity to the compound of interest.Item Síntese, caracterização e atividades biológicas de 1,2,4-oxadiazóis(2020-10-22) Silva, André Ricardo França da; Freitas Filho, João Rufino de; http://lattes.cnpq.br/9252404584350850; http://lattes.cnpq.br/6873023837824366Item Avaliação do potencial antitumoral in vitro e da atividade imunomoduladora do composto mesoiônico 5-(4-clorofenil)-3-metil-4-fenil-1,3-tiazólio-2-tiolato (MI-2)(2020-11-04) Andrade, Bárbara Fernanda Pessoa de; Silva, Elayne Cristine Soares da; Andrade, Jeyce Kelle Ferreira de; http://lattes.cnpq.br/8970644656035762; http://lattes.cnpq.br/2064359935012193; http://lattes.cnpq.br/8580695386267290Cancer is classified by the World Health Organization (WHO) as a group of diseases, wich can develop anywhere in the body, from the uncontrolled grownth of genetically altered cells and wich have the ability to invade adjacent tissues and can therefore, if install simultaneously in more than one organ. It is considered by WHO as the second leading cause of death in the world, killing about 9.6 million people. In Brazil, according to the National Cancer Institute (INCA), it is estimated that in 2020 309,750 new cases of cancer will be registered for men and about 316,280 new cases for women. Cancer patients are usually treated with chemotherapy, radiation therapy, surgical intervention and in some cases, immunotherapy. In view of the high cost and the remarkable toxicity presented by the vast majority of treatments currently available, such as weight loss and hair, in addition to anemia, leukopenia, thrombocytopenia and immunosuppression that make them extremely vulnerable; the search for new therapeutic possibilities is necessary to increase the chances of cure and quality of life. Mesoionic compounds are a group of substances defined as heterocyclic betaines, mostly of synthetic origin, biologically active and wich have been widely studied for their chemical characteristics and diverse functions, among which the antitumor potential, which has been the object of prominence, stands out of numerous surveys. The compound used in the present work (MI-2) is one of the derivatives of the thiadiazole class mesoionics called 5-(4-chlorophenyl)-3-methyl-4-phenyl-1,3-thiazolium-2-thiolate. The objective of this work was to analyze the antitumor potential of this compound, evaluating the cytotoxicity in tumor cell lines, morphological characteristics of these cells, DNA fragmentation; in addition to the analysis of cytotoxicity in cells of the imune system of rats (Rattus novergicus). The results presented so far, demonstrate satisfactory responses in antitumor evaluation tests, especially for leukemias; and a probable low toxicity in isolated rat lymphocytes. This compound is part of an ongoing research project.