01.2 - Especialização (Sede)
URI permanente desta comunidadehttps://arandu.ufrpe.br/handle/123456789/1623
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Item Achados anatomopatológicos de hipertermia por internação em cão – relato de caso(2023-02-27) Garcia, Diego Rubens Santos; Santos, Fernando Leandro dos; http://lattes.cnpq.br/4992016731387891; http://lattes.cnpq.br/4599160524370663Item Achados epidemiológicos e comparação dos achados laboratoriais de cães com infecção do trato urinário provocada por bactérias Gram-positivas e Gram-negativas(2024-02-22) Oliveira, Angélica Prado de; Guimarães, Janaina Azevedo; http://lattes.cnpq.br/8177426224558979; http://lattes.cnpq.br/9073621897539009Item Aflatoxinas B1 e M1: uma ameaça para a saúde única(2024-02-27) Buriti, Isabela Barros; Silva, Nivan Antônio Alves da; http://lattes.cnpq.br/3505011500604071; http://lattes.cnpq.br/1397684147122889In the 1960s, with the outbreak of acute liver disease in turkeys, ducklings and other birds, research began on aflatoxin poisoning in laboratory animals. After confirming the hepatotoxic potential of aflatoxins, the risk they pose to human health was also highlighted. Aflatoxin-producing fungi are capable of developing in a variety of foods, especially cereals. Strains of Aspergillus flavus produce only aflatoxins B1 and B2, while strains of Aspergillus parasiticus can produce aflatoxins B1, B2, G1 and G2. All aflatoxins are carcinogenic, with aflatoxins B1 and M1 being related to hepatocarcinogenesis. Animals and humans can develop aflatoxicosis when consuming food contaminated by any of these toxins. After ingestion, toxins are absorbed and metabolized in the liver, resulting in the production of less toxic metabolites such as AFM1, which is excreted in milk, urine, feces and bile. Acute poisoning is associated with signs such as abdominal pain, diarrhea, vomiting and pulmonary edema, and may progress to death. Chronic poisoning is related to malnutrition, immunosuppression, growth retardation, reduced reproductive performance, liver cirrhosis and hepatocellular carcinoma. Poisoned individuals may present mild anemia, alterations in liver enzymes with elevation of gamma glutamyl transferase (GGT), aspartate transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AP) and bile acids. Serum albumin may be decreased, as well as the albumin:globulin ratio. Currently, there are chemical control or decontamination techniques that can be efficient. However, the restricted and sustainable use of fungicides and the increased consumer demand for residue-free foods require the study of alternatives for the control of fungi and consequently of mycotoxins. Therefore, investments have been made in techniques that avoid contamination, in the use of biological control and adsorbents. Given the implications for unique health and economic importance of aflatoxicosis, continued study on this topic is relevant. In addition to raising awareness among the population about the forms of contamination, the development of detection tests that are efficient and rapid, as well as the implementation of control and prevention strategies that are applicable and useful.Item Avaliação da hemostasia: indicações e técnicas - revisão de literatura(2024-02-22) Silvestre, José Antonio Ramos; Teixeira, Miriam Nogueira; http://lattes.cnpq.br/7448694221629949; http://lattes.cnpq.br/2035014104576002Item Avaliação da lactato desidrogenase, proteína total e proteína c-reativa para diferenciação das efusões em cães(2021-02-22) Silva, Natália Farias da; Guimarães, Janaina Azevedo; http://lattes.cnpq.br/8177426224558979; http://lattes.cnpq.br/5757429368738176The classification of cavitary liquids expresses the composition of the effusive liquid, which can assist in the diagnosis of the pathological process and the biochemical analysis of the dosage of Lactate dehydrogenase, Total Protein and C-Reactive Protein in the analysis of cavity fluids, specifically the criteria for classifying effusions in dogs. 37 members of canine, thoracic and abdominal effusions and 14 of sera from the same animals, from the LPCV / UFRPE collection, were used. The dosages of the assignments of LDH in the liquid (LDH-L), LDH in the serum (LDH-S), Total proteins in the liquid (PT-L), Total proteins in the serum (PT-S), and PCR in the liquid (PCR- L) commercial kits and an automatic biochemical analyzer were used. The average values for each group suggested a tendency to gradually increase the measurements of all proposed parameters, with higher averages being observed in the exudate group and lower in the transudate group. The dosages were assertive in the classification of transudates in 3/3 by PT-R; 10/10 for LDH-L concentration and 4/4 for LDH-R. In exudates, the criteria were assertive on 8/9 by PT-R, 3/24 by LDH-L activity and 1/9 by LDH-R. It is concluded that there is a difference in the mean values of the variables studied in each type of effusion, with higher values in exudates. The use of LDH dosages is effective in identifying effusions, especially in identifying transudates. Further studies should be encouraged to establish reliable cut-off points for LDH and CRP for dogs.Item Avaliação do dismorfismo eritrocitário em urinas de cães(2023-02-23) Santos, Carolina Beatriz Ribeiro dos; Guimarães, Janaina Azevedo; http://lattes.cnpq.br/8177426224558979; http://lattes.cnpq.br/5975868557060997Item Biosseguridade na criação de bovinos e sua relevância para a saúde única(2023-02-27) Silva, Clara Rafaelle Cardoso da; Silva, Nivan Antônio Alves da; http://lattes.cnpq.br/3505011500604071; http://lattes.cnpq.br/8675807540589033Item Cianotoxinas: impacto na qualidade e disponibilidade de água(2023-01-31) Silva, Thailan Arlindo da; Souto, Rodolfo José Cavalcanti; http://lattes.cnpq.br/4263478911176230; http://lattes.cnpq.br/5371447938003091The Brazilian distribution of water resources, despite the significant national reserve of drinking water, occurs in a discrepant way and the decrease in water quality further reduces its supply in certain regions. In this sense, the accelerated increase in the nutritional supply in reservoirs, because of pollution from industrial, domestic and agropastoral activities, triggers the eutrophication process that culminates in the proliferation of cyanobacteria. These microorganisms have as their main characteristic of importance for unique health, the ability to produce secondary metabolites, called cyanotoxins, implicated in cases of poisoning in humans and domestic and wild animals. Given the above, the objective of this work was to analyze the impact of the presence of cyanotoxins in natural and artificial water reservoirs intended for human and animal supply. A bibliographic survey was carried out in the main national and international databases of scientific documents with subsequent elaboration of syntheses, analysis and writing of the review. From the data collected, it is possible to verify that the cyanobacteria have a wide geographic distribution, but they present ideal conditions for development and maintenance in lentic freshwater systems, enriched with nitrogen and phosphorus from anthropogenic activities, which favors the events of flowering of toxic species. Research carried out in Brazil shows that, although the Northeast region has characteristics that favor the proliferation of these microorganisms, such as varied periods of drought, poor access to basic sanitation and low water quantity in reservoirs, there are high levels of blooms of toxic cyanobacteria in reservoirs of the entire national territory. The edition and publication of specific legislation for the control and prevention of cyanotoxin intoxication in the country was driven by the only cases of deaths in humans due to microcystin intoxication in the world, which confirms the importance of the toxic blooms of these microorganisms in the unique health. In view of this, it is possible to conclude the importance of cyanotoxins as possible causes of morbidity and mortality in humans and animals in Brazil, requiring constant monitoring of their presence in water bodies in order to better structure control and prevention measures.Item Cistite bacteriana recorrente em um cão e a importância do diagnóstico laboratorial: relato de caso(2023-02-27) Mello, Thamyris Gracinda Peres Khoury de Souza; Cavalcanti, Erika Fernanda Torres Samico Fernandes; http://lattes.cnpq.br/5256493441853885; http://lattes.cnpq.br/0893156416055959Item Complexo equinococose-hidatidose e suas implicações na saúde pública(2021-09-24) Marcom, Nicoly Nayana; Souza, Maria Isabel de; http://lattes.cnpq.br/4438209268573845; http://lattes.cnpq.br/6523072892271996Echinococcosis-hydatid disease is a zoonosis caused by parasites of the genus Echinococcus, which are part of the tapeworm groups. Its cycle depends on mammals in predator and prey relation, with humans being the accidental host of the larval form of the agent, called hydatid cyst. The main species related to infection in humans are E. granulosus, E. multilocularis, E. oligarthra and E. vogeli, causing cystic, alveolar and neotropical echinococcosis, respectively. Although there are different control programs, the disease is still considered neglected in humans. In animals, it is responsible for economic losses resulting from viscera convictions and loss of carcass yield in slaughterhouses. Control measures include sanitary hygiene education of the population, control of the adult parasite in the definitive hosts and a decrease in their contact with the intermediary's viscera. Such measures receive great attention from the veterinarian, demonstrating the importance of this professional in public health. Considering the fact that the disease is considered neglected in human beings, the objective of this study is to carry out a brief review of the characteristics of the agent, the disease and its impact public health, drawing attention to its occurrence.Item Contribuições da colecistocentese percutânea guiada por ultrassom para diagnóstico de desordens do trato biliar em gatos (Felis catus)(2021-02-25) Oliveira Neta, Iraci Cordeiro de; Costa, Fabiano Séllos; http://lattes.cnpq.br/6876055943439186; http://lattes.cnpq.br/3131239010322400The present work includes two chapters. The first item discriminates against the activities carried out within the Residency Program in the Health Professional Area in Veterinary Medicine with an area of concentration in Diagnostic Imaging, held at the Veterinary University Hospital of the Federal Rural University of Pernambuco (HOVET- UFRPE), in March 2019 to February 2021. A survey of all activities carried out in the period was carried out, as well as those carried out within the scope of public health and the Unified Health System (SUS). The second chapter refers to a case report that addresses the Contributions of ultrasound-guided percutaneous cholecystocentesis for the diagnosis of biliary tract disorders in cats (Felis catus). A discussion about the technique that allows collection of material directly from the gallbladder - bile, for sending and laboratory processing and subsequent cytological, parasitological and bacterial culture analyzes.Item Coronavírus bovino: sua relevância na saúde animal e pública global(2021-10-27) Beserra, Lucas Alencar Fernandes; Silva, José Augusto Bastos Afonso da; http://lattes.cnpq.br/9754109726295756; http://lattes.cnpq.br/6178148321524675Bovine coronavirus (BCoV) is a member of the coronaviridae family. It is an important pathogen with high prevalence worldwide. This virus, a pneumoenteric agent, is responsible for the occurrence of three distinct clinical syndromes, described respectively as diarrhea in calves, dysentery in adult animals and respiratory tract affection in cattle of all ages. The presence of this virus in the herd causes substantial economic losses, also, in animal welfare and in the health of the herd. Thus, the objective of this work is to demonstrate the main characteristics of BCoV, as well as describe the occurrence of this agent in other species of domestic and wild ruminant animals. In addition, highlight the coronavirus as a zoonotic pathogen in the context of public health. Coronary virus in cattle is characterized by its enteropathogenic and respiratory forms, symbolized respectively by mucohemorrhagic enterocolitis in calves (EBCoV-CD), dysentery in adult animals (EBCoV-WD) and interstitial pneumonia (RBoV) mainly in calves. Although this agent is considered a specific pathogen of domestic cattle, its occurrence is also described in other species of domestic and wild ruminants, as well as in humans. At the interface between animals and humans, coronavirus is described as an infectious, zoonotic and emergent disease, this agent being described as the only member of the order Nidovirales to cause disease in humans. In this context, several species are incriminated as intermediate hosts in the transmission mechanism to humans, for example, dromedary camels in the transmission of MERS-COV. The role of cattle in the context of intermediate host or reservoir of this virus for humans is still poorly understood, such as the susceptibility and transmission of SARS-CoV-2. However, one of the enteric coronavirus strains in humans (HCoV-OC43) would have evolved from ancestral strains of the bovine coronavirus, which crossed the interspecies barrier and, consequently, established the infection in humans. Thus, we can consider the diseases caused by BCoV as important from an economic point of view, sanitary in the welfare of the herd, in addition to the importance of this agent in the zoonotic context, thus enabling risks to animal and human health.Item Coxielose em ruminantes e a febre Q na saúde pública no Brasil(2021-09-17) Zache, Eduardo; Torres, Alexandre Augusto Arenales; http://lattes.cnpq.br/5145322907663650; http://lattes.cnpq.br/9715170506304327Q fever is a zoonosis of worldwide distribution caused by Coxiella burnetii, a gram-negative obligate intracellular bacterium of the order Legionellales, which has been classified as a potential bioterrorism agent. Thus, the present study aims to perform a literature review on Q fever and coxiellosis, with emphasis on its close relationship to public health, due to its zoonotic nature, in addition to its economic importance for national livestock. Cattle and small ruminants represent the most frequent sources of infection in humans, with inhalation of contaminated aerosols from infected animal products being the main form of transmission. The high occupational risk is related mainly to cattle and small ruminant breeders and veterinarians, even people with sporadic contact with animals, such as employees in veterinary clinics. Infections in humans are usually asymptomatic, but can evolve into serious complications such as endocarditis, which can be fatal if not treated appropriately. In ruminants the most important clinical manifestations are reproductive disorders such as abortion, stillbirth fetus, endometritis, infertility and mastitis, but the agent has also been identified in cattle with endocarditis. The clinical diagnosis is difficult, due to the nonspecificity of the clinical signs. Specific indirect diagnostic tools such as the indirect microimmunofluorescence test is considered a reference technique for humans, however for ruminants the molecular method of polymerase chain reaction (PCR) is a reliable method to detect the elimination of the agent in body fluids (feces, milk and vaginal mucus) that may be intermittent. The prophylactic combination of doxycycline and hydroxychloroquine has been shown to be effective in preventing endocarditis and is indicated in the presence of risk factors in humans. In animals, the use of antimicrobials has not been effective. In recent years, several cases of C. burnetii infection in humans and animals have been reported in Brazil, with evidence of Q fever circulating in humans in the southeast and northeast regions, and in animals in the southeast, central-west and northeast regions. The Ministry of Agriculture, Livestock and Supply classifies the disease in category 3 (three) of the list of diseases of mandatory notification to the Veterinary Service, however, it is not recognized by the Brazilian Ministry of Health as of mandatory notification in humans. With all zoonotic diseases, the control of the disease in animals and the interdisciplinary following the principles of One Health, will directly influence the results observed in humans.Item Criptosporidiose em ruminantes e sua importância em saúde pública(2018) Macedo, Darlan Rodrigues; Cajueiro, Jobson Filipe de Paula; http://lattes.cnpq.br/1163226949462180; http://lattes.cnpq.br/8208793638612108Cryptosporidiosis is an important disease in cattle breeding, calves up to 30 days of age being the most susceptible category. The etiological agents are protozoans of the genus Cryptosporidium, which complete their cycle in respiratory, urinary and gastrointestinal epithelial cells of birds, reptiles and mammals including man. The route of infection is fecal-oral. The infection occurs after ingestion of food and water contaminated with sporulated oocysts, which contain sporozoites inside. Production animals mainly calves are the main sources of environmental contamination and therefore an important risk factor for other animals and man. The clinical manifestation of the disease is due to the lesions in the gastrointestinal tract that occur through the rupture of enterocytes with persistent and watery diarrhea. Diarrhea is the main cause of death in calves up to 30 days old, being one of the main agents Criptosporidium sp. Cryptosporidiosis is a zoonosis with a worldwide distribution, with children between the ages of 1 and 5 years, adults being transplanted and immunocompromised individuals, high risk groups, where this enteroparasite can cause severe enteritis and may lead to death. However, immunocompetent adults may present with diarrheal episodes. Diarrhea is the main cause of death in calves up to 30 days old, being one of the main agents Criptosporidium sp. Cryptosporidiosis is a zoonosis with a worldwide distribution, being children from 1 to 5 years of age, transplanted adults and immunocompromised individuals, high risk groups, in which this enteroparasite can cause serious enteritis and may lead to death. However, immunocompetent adults may present with diarrheal episodes. Risk factors include contact with sick animals or carriers, together with lack of adequate hygiene habits and basic sanitation. Prophylaxis consists of vaccination of pregnant cows, the use of some drugs that help prevent diarrhea, as well as reduce the amount of oocysts removed in the faeces, correct administration of colostrum and, in cases of sick animals, supportive therapy for the reestablishment of the hydroeletrilic balance and basic acid. Other factors such as parasite resistance in the environment and disinfectants, lack of knowledge by health professionals about epidemiology and diagnostic methods, and ineffective treatment make it a major public health problem in the world.Item Cultivo e linhagens celulares aplicadas na biotecnologia e no diagnóstico virológico da medicina veterinária: revisão de literatura(2023-02-27) Almeida, Bárbara Ferreira de; Pinheiro Junior, José Wilton; http://lattes.cnpq.br/3931532041328673; http://lattes.cnpq.br/2329583516227520The objective of this Residency Conclusion Work (TCR) was to describe the activities of the residency in Preventive Veterinary Medicine - Animal Virology, developed in the Laboratory of Animal Virology (LAVIAN), in the area of Preventive Veterinary Medicine - Animal Virology, as well as to perform a literature review on cell culture. During the residency period compulsory subjects were studied, divided into: common core mandatory for all areas, specific core of the concentration area and common core of the concentration area. At LAVIAN training activities were developed on collection and processing of biological material; diagnostic techniques applied to the diagnosis of viral diseases; interpretation of results; application of biosafety rules and laboratory organization of materials, reagents, samples and assets. Besides the theoretical and practical activities at LAVIAN, activities were developed at the Brazilian National Health System (SUS), in the following areas: Health Surveillance, Epidemiological Surveillance and Environmental Surveillance. The residency program is important for building a more solid professional career, directed to a specialty, and from where many professional and personal teachings are born. The cell culture technique and the different cell lines are extremely important for Biotechnology in human health and in Veterinary Medicine. Its improvement over the years has provided molecular biology and virology with more precise diagnoses and more efficient products.Item Doença de chagas sob a perspectiva da saúde única(2024-02-21) Dionizio, José Alexandre Rocha; Coutinho, Luiz Teles; http://lattes.cnpq.br/8812254003382110; http://lattes.cnpq.br/2632759634584338American trypanosomiasis, also known as Chagas disease (CD) in Brazil, is an illness caused by the protozoan Trypanosoma cruzi. To complete its life cycle, the etiological agent depends on the presence of insect vectors from the Triatominae genus, commonly known as kissing bugs. Other transmission modes include the ingestion of food contaminated with fragments and/or secretions from triatomines, transfusion of contaminated blood, transplacental transmission, and accidental contact with contaminated objects. The complications of the disease can lead to cardiovascular alterations, megaesophagus, constipation, and intestinal obstruction in chronic patients. In acute cases, symptoms such as fever, inoculation chagoma, Romaña's sign, malaise, lymphadenopathy, and hepatosplenomegaly may be observed. The prevalence of CD in Brazil varies by region due to specific risk factors such as living conditions, dietary habits, peridomestic animal rearing, population education level, and the presence of different species and food sources for triatomines, contributing to the diversity of cases. Despite being a long-recognized disease, there are only two therapeutically effective drugs officially approved and available from the Ministry of Health: benznidazole and nifurtimox. Both drugs have adverse effects and require strict dosing regimens. The main prophylactic strategies involve controlling the vectors to break the biological cycle of the agent. However, transmission through the ingestion of contaminated food has gained prominence, particularly in regions of Brazil where the consumption of products such as açaí, cupuaçu, and sugarcane juice is common. This underscores the need for more rigorous sanitary-hygienic regulations for these raw products. This literature review aims to address the main etiological, epidemiological, clinical, therapeutic, and preventive aspects of CD from a public health perspective. Additionally, it highlights the importance of veterinarians in controlling this zoonosis, which, though often neglected, still affects a significant portion of the Brazilian population.Item Emprego de antimicrobianos na pecuária bovina e suas implicações na saúde pública(2021-12-15) Gomes, Lucas da Silva Ferreira; Coutinho, Luiz Teles; http://lattes.cnpq.br/8812254003382110; http://lattes.cnpq.br/6350534197203776The use of antimicrobials (ATM) in ruminants is a tool responsible for a significant boost in animal production by reducing morbidity and mortality rates arising from health problems, thus providing an improvement in the health profile and production rates, and consequently greater quality and safety of animal foods. However, the high adaptability of the bacterial cell associated with the selective pressure imposed by the indiscriminate use of ATM's in animals and also in humans, has been promoting the development of antimicrobial resistance (AMR) worldwide, which is one of the most important problems that reaches and links Human and Veterinary Medicine, as both share the use of a range of common ATM's, combined with the fact that antimicrobial resistant bacteria (ARB's) and antimicrobial resistance related genes (ARG's) can be transferred between animals, the environment and human beings, making this phenomenon a unique global health problem. The need for constant monitoring of the use of ATM is highlighted, in order to contain the emergence and/or expansion of resistant bacterial strains, as well as the integration between professionals in the mobilization of society as a whole in order to preserve the unique health. In this context, the objective was to carry out this literature review on some aspects of the use of antimicrobials in cattle, as well as the emergence of resistant bacterial strains and their impacts on public health.Item Erros pré-analíticos: avaliação das não conformidades em amostras sanguíneas encaminhadas ao laboratório de patologia clínica veterinária do hospital veterinário da UFRPE(2023-02-23) Silva, Lucas Cavalcante; Teixeira, Miriam Nogueira; http://lattes.cnpq.br/7448694221629949; http://lattes.cnpq.br/4276330694413367Complementary exams are important tools in clinical decision-making. With technological advances, there is an increase in diagnostic information and, consequently, the importance of the quality of the results obtained. However, for greater reliability of the tests, the period from filling out the request to delivering the sample to the laboratory, called the pre-analytical phase, deserves a lot of attention. The objective was to identify and describe the frequencies of nonconformities found during the pre-analytical phase in blood samples sent for blood count at the Laboratory of Veterinary Clinical Pathology at HOVET-UFRPE, supporting decision-making for the correction and prevention of such problems. During the months of March to May 2022, the collection of samples for blood count sent from the daily routine in the laboratory was carried out. Among the 791 samples, 317 (40.07%) had some pre-analytical error, with most cases referring to the canine species, in agreement with the hospital casuistry. Errors were grouped into three groups involving sample quality, requisition and collection tube. In the first group, the main alteration found was hemolysis, in 37.87% of the samples; followed by lipemia. In the second, we have incomplete completion of the requisitions and illegible handwriting with 34% and 15.5%, respectively, and, to a lesser extent, the absence of identification of the collection tube representing the third group. The results are below those found in the literature due to the logistics of delivery and control by the laboratory, however, they represent almost half of the total received. The computerization of the hospital system and awareness of the improvement in the pre-analytical phase are possible promising resolutions.Item Esporotricose no contexto da saúde única(2023-10-31) Nascimento, Wellington de Souza; Afonso, José Augusto Bastos; http://lattes.cnpq.br/9754109726295756; http://lattes.cnpq.br/8738450850987099Implantation, or subcutaneous, mycoses are a group of diseases caused by fungi that are characterized by the inoculation of the agent through transcutaneous trauma. They are called implantation mycoses because some of these diseases can affect other tissues of the body, in addition to the subcutaneous tissue. As is the case with sporotrichosis, an implantation mycosis caused by dimorphic fungi of the genus Sporothrix. Thus, the objective is to evaluate the epidemiological aspects of sporotrichosis in the context of Single Health through a literature review. The review on sporotrichosis was carried out through research in the following renowned databases of national and international literature: BDTD Nacional, Scopus, Periodicos CAPES, PubMed, Scielo, Biblioteca Virtual em Saúde and Google Scholar, using sporotrichosis and public health as the main words -chaves, both in portuguese and english. As a large number of files were recovered, 47 files were selected that best suited the research theme. Classically, sporotrichosis is transmitted by the inoculation of the fungus through trauma caused by contact with contaminated organic matter such as soil, branches and tree trunks and thorns, but since the 1990s, it has become of great relevance in public health in Brazil, when the first outbreak of disease in humans was described with the domestic cat as the main inoculator, in the state of Rio de Janeiro. It is more prevalent in regions with a tropical and temperate climate. In Brazil, like much of the world, the disease is neglected and is not part of the compulsory notification diseases and diseases. Clinical manifestations in humans are related to the location where the lesions are located and their extent, with cutaneous lesions being more common and pulmonary lesions being more common in extracutaneous involvement. In animals, it is mainly represented by cats, which present ulcerative and/or nodular lesions mainly in the nasal region, chest and extremities. The implementation of effective and standard health surveillance emerges as a necessity so that there is real data on the disease in the national territory. It is necessary to work together in the human, animal and environmental spheres to adopt actions and measures based on these three pillars to better understand the disease. Providing free and rapid diagnosis for cats appears as an incentive for the population to seek official health services to identify the disease. In addition, raising awareness among health professionals and the general population is extremely important for control to be effective.Item Hemangiossarcoma cutâneo em felino: relato de caso(2021-02-24) Monteiro, Lorena Lúcia Cardoso; Andrade, Lílian Sabrina Silvestre de; http://lattes.cnpq.br/0894888392191039; http://lattes.cnpq.br/9492872765218361