Navegando por Autor "Silva, Lucas Cavalcante"

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Anemia hemolítica imunomediada: diagnóstico e terapêutica
(2019-12-11) Silva, Lucas Cavalcante; Coutinho, Tania Alen; Almeida, Talles Monte de; http://lattes.cnpq.br/2215902008831775; http://lattes.cnpq.br/1916619528141219; http://lattes.cnpq.br/4276330694413367
Immunomediated hemolytic anemia is a clinical syndrome resulting from the accelerated destruction of red blood cells by immunomediated mechanisms. Clinical signs associated to this syndrome are generally nonspecific, such as paleness, weight loss, petechiae, ecchymoses, lymphadenopathy, and hepatomegaly, however, manifestations related directly to hemolysis can also be verified, which include splenomegaly, jaundice, and hemoglobinuria or bilirubinuria. Such disease impairs tissue oxygenation bringing risks to the patient's health. Regarding to the diagnostic definition of immune-mediated hemolytic anemia, there is no gold standard laboratory test yet, and it is being achieved by the combination of patient clinical presentation, laboratory findings and immunological tests. For the therapeutic control, the use of corticoid therapy associated or not with anticoagulants is essential, due to the risk of thromboembolism in this disturb, as well as the implementation of transfusion support therapy, especially from concentrate of red blood cells, which will not interfere with blood volume, minimizing the risk of immune reactions. Thus, in view of the homeostatic damage generated by immunomediated hemolytic anemia to patient’s health, as well as its frequent occurrence in the veterinary clinic of small animals, it was the aim of the present undergraduate thesis to review the theme.
Erros pré-analíticos: avaliação das não conformidades em amostras sanguíneas encaminhadas ao laboratório de patologia clínica veterinária do hospital veterinário da UFRPE
(2023-02-23) Silva, Lucas Cavalcante; Teixeira, Miriam Nogueira; http://lattes.cnpq.br/7448694221629949; http://lattes.cnpq.br/4276330694413367
Complementary exams are important tools in clinical decision-making. With technological advances, there is an increase in diagnostic information and, consequently, the importance of the quality of the results obtained. However, for greater reliability of the tests, the period from filling out the request to delivering the sample to the laboratory, called the pre-analytical phase, deserves a lot of attention. The objective was to identify and describe the frequencies of nonconformities found during the pre-analytical phase in blood samples sent for blood count at the Laboratory of Veterinary Clinical Pathology at HOVET-UFRPE, supporting decision-making for the correction and prevention of such problems. During the months of March to May 2022, the collection of samples for blood count sent from the daily routine in the laboratory was carried out. Among the 791 samples, 317 (40.07%) had some pre-analytical error, with most cases referring to the canine species, in agreement with the hospital casuistry. Errors were grouped into three groups involving sample quality, requisition and collection tube. In the first group, the main alteration found was hemolysis, in 37.87% of the samples; followed by lipemia. In the second, we have incomplete completion of the requisitions and illegible handwriting with 34% and 15.5%, respectively, and, to a lesser extent, the absence of identification of the collection tube representing the third group. The results are below those found in the literature due to the logistics of delivery and control by the laboratory, however, they represent almost half of the total received. The computerization of the hospital system and awareness of the improvement in the pre-analytical phase are possible promising resolutions.